Kawata N, Hirakata H, Igarashi T, Minei S, Hamano K, Kodama M, Yamamoto T, Takimoto Y
Department of Urology, Nihon, University Surugadai Hospital.
Hinyokika Kiyo. 1996 Jul;42(7):509-12.
Previously, we reported a case of complete response (CR) of metastatic renal cell carcinoma with inhalant interferon-gamma. This inhalant therapy was considered effective against metastatic lung hilar tumors. On the other hand, metastatic tumors of the peripheral lung field tumor did not respond to the inhalation therapy. We report, a case of metastatic renal cell carcinoma in peripheral lungs showing complete response to continuous subcutaneous administration of interferon alpha and gamma. A 53-year-old woman was admitted to our hospital because of a large palpable mass in the left upper quadrant in March, 1994. Computerized tomographic (CT) scan disclosed a huge renal tumor. To reduce the tumor size, transarterial embolization, and subcutaneous administration of interferon-gamma were performed. In April 1994, the tumor was completely excised. In the post-operative course, multiple metastases were recognized in the lower peripheral lung field, subcutaneous administration of IFN-gamma and inhalation of IFN-gamma were begun, but the tumor size increased in October 1994. She underwent continuous subcutaneous administration of IFN-alpha and gamma. Three months later, the lung tumor disappeared. She has remained tumor-free as of October 1995. We concluded that this therapy may be effective against metastatic renal cell carcinoma in the lungs.
此前，我们报道了一例转移性肾细胞癌经吸入干扰素-γ实现完全缓解（CR）的病例。这种吸入疗法被认为对转移性肺门肿瘤有效。另一方面，肺外周野肿瘤的转移瘤对吸入疗法无反应。我们报告一例肺外周转移性肾细胞癌经连续皮下注射干扰素α和γ后实现完全缓解的病例。一名53岁女性于1994年3月因左上腹可触及巨大肿块入住我院。计算机断层扫描（CT）显示一个巨大的肾肿瘤。为缩小肿瘤大小，进行了经动脉栓塞术，并皮下注射干扰素-γ。1994年4月，肿瘤被完全切除。在术后过程中，在肺外周下野发现多处转移，开始皮下注射干扰素-γ和吸入干扰素-γ，但1994年10月肿瘤大小增大。她接受了干扰素α和γ的连续皮下注射。三个月后，肺部肿瘤消失。截至1995年10月，她一直无肿瘤复发。我们得出结论，这种疗法可能对肺部转移性肾细胞癌有效。
