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Acquired methotrexate resistance in lymphoblasts resulting from altered kinetic properties of dihydrofoltate reductase.

作者信息

Jackson R C, Niethammer D

出版信息

Eur J Cancer (1965). 1977 Jun;13(6):567-75. doi: 10.1016/0014-2964(77)90118-9.

DOI:10.1016/0014-2964(77)90118-9
PMID:880964
Abstract
摘要

相似文献

1
Acquired methotrexate resistance in lymphoblasts resulting from altered kinetic properties of dihydrofoltate reductase.由于二氢叶酸还原酶动力学特性改变导致淋巴母细胞获得性甲氨蝶呤耐药。
Eur J Cancer (1965). 1977 Jun;13(6):567-75. doi: 10.1016/0014-2964(77)90118-9.
2
Methods and mechanisms for the development of MTX resistance in human lymphoid cells.人类淋巴细胞中MTX耐药性产生的方法和机制。
Int J Cancer. 1983 Jan 15;31(1):45-50. doi: 10.1002/ijc.2910310108.
3
Increase of dihydrofolate reductase activity in cultured mammalian cells after exposure to methotrexate.暴露于甲氨蝶呤后培养的哺乳动物细胞中二氢叶酸还原酶活性的增加。
Proc Natl Acad Sci U S A. 1967 Oct;58(4):1632-7. doi: 10.1073/pnas.58.4.1632.
4
Purification and characterization of dihydrofolate reductase from methotrexate-resistant human lymphoblastoid cells.来自甲氨蝶呤耐药人淋巴母细胞样细胞的二氢叶酸还原酶的纯化与特性分析
Biochemistry. 1983 Feb 1;22(3):633-9. doi: 10.1021/bi00272a017.
5
Kinetic investigation of methotrexate resistant human dihydrofolate reductase (hDHFR) mutants at Phe31.
Adv Exp Med Biol. 1993;338:507-10. doi: 10.1007/978-1-4615-2960-6_102.
6
Effects of methotrexate esters and other lipophilic antifolates on methotrexate-resistant human leukemic lymphoblasts.甲氨蝶呤酯及其他亲脂性抗叶酸剂对耐甲氨蝶呤的人白血病淋巴母细胞的作用。
Biochem Pharmacol. 1980 Feb 15;29(4):648-52. doi: 10.1016/0006-2952(80)90391-3.
7
Quantitation of dihydrofolate reductase in individual parental and methotrexate-resistant murine cells. Use of a fluorescence activated cell sorter.
J Biol Chem. 1978 Aug 25;253(16):5852-60.
8
Dual consequence of mutation in the dihydrofolate reductase gene of Diplococcus pneumoniae.肺炎双球菌二氢叶酸还原酶基因突变的双重后果。
Biochem Biophys Res Commun. 1969 Aug 15;36(4):603-7. doi: 10.1016/0006-291x(69)90347-7.
9
Properties of dihydrofolate reductase from a methotrexate-resistant subline of human KB cells and comparison with enzyme from KB parent cells and mouse S180 AT/3000 cells.来自人KB细胞甲氨蝶呤抗性亚系的二氢叶酸还原酶的特性及其与KB亲本细胞和小鼠S180 AT/3000细胞的酶的比较。
Mol Pharmacol. 1982 Jan;21(1):231-8.
10
Methotrexate-resistant human promyelocytic leukemia (HL-60) cells express a dihydrofolate reductase with altered properties associated with increased enzyme activity.对甲氨蝶呤耐药的人早幼粒细胞白血病(HL-60)细胞表达一种二氢叶酸还原酶,其性质改变与酶活性增加有关。
Biochem Biophys Res Commun. 1985 Jun 14;129(2):536-45. doi: 10.1016/0006-291x(85)90185-8.

引用本文的文献

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Synthesis, Biological Activity, and Molecular Dynamics Study of Novel Series of a Trimethoprim Analogs as Multi-Targeted Compounds: Dihydrofolate Reductase (DHFR) Inhibitors and DNA-Binding Agents.新型系列三甲氧嘧啶类似物的合成、生物活性及分子动力学研究:二氢叶酸还原酶(DHFR)抑制剂和 DNA 结合剂的多靶点化合物。
Int J Mol Sci. 2021 Apr 1;22(7):3685. doi: 10.3390/ijms22073685.
2
Optimized peptide based inhibitors targeting the dihydrofolate reductase pathway in cancer.针对癌症中二氢叶酸还原酶途径的优化肽类抑制剂。
Sci Rep. 2018 Feb 16;8(1):3190. doi: 10.1038/s41598-018-21435-5.
3
Tomudex (ZD1694): from concept to care, a programme in rational drug discovery.
拓姆替克(ZD1694):从概念到医疗,合理药物研发项目
Invest New Drugs. 1996;14(3):305-16. doi: 10.1007/BF00194534.
4
Chemotherapeutic drug resistance in the management of head and neck cancer.头颈部癌治疗中的化疗耐药性。
Eur Arch Otorhinolaryngol. 1993;250(4):200-8. doi: 10.1007/BF00171524.
5
The in vivo distribution of methotrexate between plasma and erythrocytes.甲氨蝶呤在血浆和红细胞之间的体内分布。
Cancer Chemother Pharmacol. 1982;9(2):110-3. doi: 10.1007/BF00265389.
6
Isolation and expression of an altered mouse dihydrofolate reductase cDNA.一种改变的小鼠二氢叶酸还原酶cDNA的分离与表达
Proc Natl Acad Sci U S A. 1983 May;80(9):2495-9. doi: 10.1073/pnas.80.9.2495.
7
Overproduction of dihydrofolate reductase and gene amplification in methotrexate-resistant Chinese hamster ovary cells.甲氨蝶呤耐药的中国仓鼠卵巢细胞中二氢叶酸还原酶的过量产生与基因扩增
Mol Cell Biol. 1982 Mar;2(3):275-85. doi: 10.1128/mcb.2.3.275-285.1982.
8
Development of methotrexate resistance in a human squamous cell carcinoma of the head and neck in culture.培养的人头部和颈部鳞状细胞癌中甲氨蝶呤耐药性的发展。
Proc Natl Acad Sci U S A. 1984 May;81(9):2873-7. doi: 10.1073/pnas.81.9.2873.
9
Prognostic importance of systemic clearance of methotrexate in childhood acute lymphoblastic leukemia.
Cancer Chemother Pharmacol. 1987;19(3):261-4. doi: 10.1007/BF00252984.
10
Systemic resistance to methotrexate in transgenic mice carrying a mutant dihydrofolate reductase gene.携带突变二氢叶酸还原酶基因的转基因小鼠对甲氨蝶呤的全身抗性。
Proc Natl Acad Sci U S A. 1986 Dec;83(24):9621-5. doi: 10.1073/pnas.83.24.9621.