Milin J, Demajo M, Todorovic V
Department of Pathology and Histology, Medical Faculty, Vinca, Belgrade.
Neuroscience. 1996 Aug;73(3):845-54. doi: 10.1016/0306-4522(96)00014-0.
The pineal gland-reactive response to long-term multifactor stress inducement performed by 18 h immobilization was found in the occurrence of different pinealocyte forms--cells of the basal activity, functionally animated cells and cells assumed to be threatened by an irreversible injury. Functionally animated pinealocytes were recognized as entities of neuroendocrine-like and ependymal-like activities displaying an episode of their initially increased secretory activity determined by Golgi apparatus and succeeded by a period determined by the storage of compounds arising from the cisterns of the granular reticulum. The domination of the pinealocytes with neuroendocrine-like activity was considered to evince a stimulated, peptidergic-mediated pineal gland activity. The adrenocorticotropic hormone-reactive secretion, employed as the evaluation parameter in morphofunctional observations, corroborated the morphologically estimated increased pineal gland activity in long-term stress inducement.
通过18小时固定进行长期多因素应激诱导后，在不同松果体细胞形式（基础活性细胞、功能活跃细胞和被认为受到不可逆损伤威胁的细胞）的出现中发现了松果体反应。功能活跃的松果体细胞被认为是具有神经内分泌样和室管膜样活动的实体，其最初的分泌活动增加由高尔基体决定，随后是由颗粒网状池产生的化合物储存期。具有神经内分泌样活性的松果体细胞占主导地位被认为表明松果体活性受到刺激，由肽能介导。促肾上腺皮质激素反应性分泌作为形态功能观察中的评估参数，证实了长期应激诱导下形态学估计的松果体活性增加。
