Lund-Andersen H, Moller M
Exp Brain Res. 1977 May 23;28(1-2):37-50. doi: 10.1007/BF00237084.
Light and electron microscope autoradiography indicated that 3H-labelled inulin was taken up by neurons and glia cells of rat brain cortex in vitro. The mechanism, by which inulin passed the cell membranes, was studied by comparing the transport of inulin (molecular weight 5000) with the transport of dextran (molecular weight 75000). The half-time for the cellular in- and efflux for the two molecules was the same although their diffusion coefficients differed by a factor of 4-5. The transport mechanism was therefore interpreted as bulk transport, and vesicular transport is suggested. Efflux of inulin from brain cortex exposed to inulin in vivo indicated that cellular uptake of inulin also occurred in vivo.
光学显微镜和电子显微镜放射自显影表明，体外培养时大鼠大脑皮层的神经元和神经胶质细胞摄取了3H标记的菊粉。通过比较菊粉（分子量5000）和右旋糖酐（分子量75000）的转运情况，研究了菊粉通过细胞膜的机制。尽管这两种分子的扩散系数相差4至5倍，但它们进出细胞的半衰期相同。因此，转运机制被解释为批量转运，并提示存在囊泡转运。体内暴露于菊粉的大脑皮层中菊粉的外流表明，体内也发生了菊粉的细胞摄取。
