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膀胱癌放疗失败后行膀胱切除术作为“最后手段”(作者译)

[Cystectomy as "ultima ratio" after failure of radiotherapy in bladder cancer (author's transl)].

作者信息

Klippel K F, Altwein J E

出版信息

Urologe A. 1979 May;18(3):118-21.

PMID:88112
Abstract

20 patients were cystectomized an average of 2 years after unsuccessful curative radiotherapy. This technically difficult procedure has a high mortality rate of about 10--20%. None of the patients survived more than 5 years, but improved quality of life was the main subjective impression. A tumor-free specimen -- the effect of radio-induced downstaging -- is no guarantee of long-term survival. 4 of 6 patients without histological tumor cells in the cystectomy or lymph node specimens died of metastic disease. The indications for "salvage" cystectomy were: untreatable bladder hemorrhage, in some instances as emergency; frequently recurrent tumors; and subjectively unbearable state of disease.

摘要

20例患者在根治性放射治疗失败后平均2年接受了膀胱切除术。这个技术难度较大的手术死亡率较高,约为10% - 20%。没有患者存活超过5年,但生活质量改善是主要的主观感受。无肿瘤标本——放射诱导降期的效果——并不能保证长期生存。在膀胱切除术或淋巴结标本中无组织学肿瘤细胞的6例患者中有4例死于转移性疾病。“挽救性”膀胱切除术的指征为:无法治疗的膀胱出血,在某些情况下作为急诊处理;频繁复发的肿瘤;以及患者主观上难以忍受的疾病状态。

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