Breton B, Sambroni E
Laboratoire de Physiologie des Poissons INRA, Rennes, France.
Gen Comp Endocrinol. 1996 Feb;101(2):155-64. doi: 10.1006/gcen.1996.0017.
Testosterone and estradiol were implanted into triploid rainbow trout, and their effects on brain and pituitary salmon gonadotropin-releasing hormone (sGnRH) content and on gonadotropin (GtH2) levels in the pituitary and blood were studied. In the hypothalamic areas, neither steroid altered sGnRH content. In the brain tissues (ventral telencephalon and preoptic areas), testosterone (0.5 mg/kg BW) significantly increased sGnRH contents and larger doses induced a more rapid increase. Estradiol induced a similar increase which occurred later than the response to the same dose of testosterone. Both steroids also stimulated pituitary sGnRH, with estradiol being less potent. Only testosterone induced long-term increases in plasma GtH2 content. Both steroids may act on the synthesis and release of GnRH, with testosterone having a greater influence on the control of gonadotropin secretion, especially at the end of the cycle.
将睾酮和雌二醇植入三倍体虹鳟鱼体内，研究它们对脑和垂体中鲑鱼促性腺激素释放激素（sGnRH）含量以及垂体和血液中促性腺激素（GtH2）水平的影响。在下丘脑区域，两种类固醇均未改变sGnRH含量。在脑组织（腹侧端脑和视前区）中，睾酮（0.5mg/kg体重）显著增加sGnRH含量，更大剂量则诱导更快增加。雌二醇诱导了类似的增加，但比相同剂量睾酮的反应出现得更晚。两种类固醇也刺激垂体sGnRH，雌二醇的作用较弱。只有睾酮诱导血浆GtH2含量长期增加。两种类固醇可能作用于GnRH的合成和释放，睾酮对促性腺激素分泌的控制影响更大，尤其是在周期末期。
