Brunialti A L, Harding C O, Wolff J A, Guénet J L
Institut Pasteur à Paris, 25 rue du Docteur Roux, Paris Cedex 15, 75724, France.
Genomics. 1996 Aug 15;36(1):182-4. doi: 10.1006/geno.1996.0442.
The autosomal recessive mouse mutation sarcosinemia (sar), which was discovered segregating in the progeny of a male whose premeiotic germ cells had been treated with the mutagen ethylnitrosourea, is characterized by a deficiency in sarcosine dehydrogenase activity. Using an intersubspecific cross, we mapped the sar locus to mouse chromosome 2, approximately 15-18 cM from the centromere. The genetic localization of this locus in the mouse allows the identification of a candidate region in human (9q33-q34) where the homologous disease should map.
