Noben-Trauth K, Copeland N G, Gilbert D J, Jenkins N A, Sonoda G, Testa J R, Klempnauer K H
Jackson Laboratory, Bar Harbor, Maine 04609, USA.
Genomics. 1996 Aug 1;35(3):610-2. doi: 10.1006/geno.1996.0408.
Mybl2 encodes a transcription factor that is thought to play an important role in cell cycle progression. Here we report the chromosomal localization of Mybl2 in mouse and human. Using mouse Mybl2 cDNA clones as probes, we assigned Mybl2 in an interspecific backcross panel to distal Chromosome 2. Using human cDNA probes in combination with FISH analysis, we localized MYBL2 to chromosome 20q13.1, a region that is commonly deleted in myeloid disorders. Both chromosomal regions are highly homologous, and the map positions, therefore, confirm each other. However, our findings are in contrast to a previous report by Barletta et al. (Cancer Res. 51:3821-3824, 1991) that placed the MYBL2 gene on human chromosome Xq13.
Mybl2编码一种转录因子，该转录因子被认为在细胞周期进程中发挥重要作用。在此，我们报告Mybl2在小鼠和人类中的染色体定位。使用小鼠Mybl2 cDNA克隆作为探针，我们在种间回交群体中将Mybl2定位到2号染色体远端。使用人类cDNA探针结合荧光原位杂交分析，我们将MYBL2定位到20q13.1染色体，该区域在髓系疾病中通常缺失。这两个染色体区域高度同源，因此图谱位置相互印证。然而，我们的发现与Barletta等人（《癌症研究》51:3821 - 3824, 1991）之前的一份报告相反，该报告将MYBL2基因定位在人类Xq13染色体上。
