Ohta T, Gillespie JH
National Institute of Genetics, , Mishima, , 411, Japan
Theor Popul Biol. 1996 Apr;49(2):128-42. doi: 10.1006/tpbi.1996.0007.
A short history of the major features of neutral theories of molecular evolution is presented. Emphasis is placed on the nearly neutral theory, as this version of the neutral theory has explained the widest range of phenomena. The shift of interest from protein to DNA evolution is chronicled, leading to the modern view that silent and replacement substitutions are responding to different evolutionary forces. However, the exact nature and magnitude of these forces remains controversial, as all current theoretical models suffer either from assumptions that are not quite realistic or from an inability to account readily for all phenomena. Although the gathering of sequence data has been the main effort of contemporary population genetics, further exploration of theoretical models of molecular evolution would provide a more coherent framework for data analysis.
本文介绍了分子进化中性理论主要特征的简史。重点放在近中性理论上，因为这个版本的中性理论解释了最广泛的现象。文中记载了从蛋白质进化到DNA进化的研究兴趣转变，从而形成了现代观点，即沉默替换和替换替换对不同的进化力量做出反应。然而，这些力量的确切性质和大小仍存在争议，因为所有当前的理论模型要么存在不太现实的假设，要么无法轻易解释所有现象。尽管序列数据的收集一直是当代群体遗传学的主要工作，但进一步探索分子进化的理论模型将为数据分析提供一个更连贯的框架。
