长期缺血后盐酸倍他美兰治疗对沙土鼠海马胆碱能系统的影响。

The effect of long-term post-ischemic bifemelane hydrochloride treatment on cholinergic systems in the gerbil hippocampus.

作者信息

Huang Y L, Onodera H, Takeda A, Itoyama Y, Kogure K

机构信息

Department of Neurology, Tohoku University School of Medicine, Sendai, Japan.

出版信息

Brain Res. 1996 May 25;722(1-2):195-9. doi: 10.1016/0006-8993(96)00192-8.

DOI:10.1016/0006-8993(96)00192-8

PMID:8813367

Abstract

Bifemelane hydrochloride (BF) is a modulator of various neurotransmitter systems. The effect of BF on the cholinergic system was studied in the gerbil hippocampus at 100 days after ischemic damage. Marked enhancement of AChE staining was noticed in the CA1 of saline-treated animals at 100 days after ischemia, while the post-ischemic enhancement of AChE staining intensity was milder in BF-treated animals. Muscarinic receptor density was markedly decreased in the CA1 subfield after ischemia. Interestingly, BF-treated animals showed higher muscarinic receptor binding in many brain areas, particularly in the dentate gyrus. These results indicate that BF modulates cholinergic neuronal plasticity in the ischemic hippocampus after long-term survival.

摘要

盐酸比芬美兰（BF）是一种多种神经递质系统的调节剂。在缺血损伤100天后，研究了BF对沙鼠海马胆碱能系统的影响。在缺血后100天，生理盐水处理的动物海马CA1区乙酰胆碱酯酶（AChE）染色明显增强，而BF处理的动物缺血后AChE染色强度的增强则较轻微。缺血后海马CA1亚区毒蕈碱受体密度明显降低。有趣的是，BF处理的动物在许多脑区，特别是齿状回，显示出更高的毒蕈碱受体结合。这些结果表明，BF可调节长期存活后缺血海马中的胆碱能神经元可塑性。