Scarpignato C
Department of Gastro-Enterology and Hepatology, Faculty of Medicine, University of Nantes, France.
Digestion. 1996;57 Suppl 1:114-8. doi: 10.1159/000201413.
Following gastric surgery, 25-50% of patients experience dumping symptoms. Early dumping usually involves both gastro-intestinal and vasomotor complaints, while late dumping involves mainly the latter. Management is mainly achieved by dietary modification. Drug therapy has been investigated, without consistent success. However, the somatostatin analogue octreotide alleviates dumping by slowing gastric emptying, inhibiting insulin release, decreasing enteric peptide secretion and intestinal absorption of water and sodium, slowing monosaccharide absorption, increasing gut transit time and preventing haemodynamic changes. The short-term efficacy of octreotide has been confirmed in five randomised, controlled trials. Promising results are also available from long-term studies on a limited number of patients.
胃手术后，25%至50%的患者会出现倾倒症状。早期倾倒通常涉及胃肠道和血管运动方面的不适，而晚期倾倒主要涉及后者。治疗主要通过饮食调整来实现。药物治疗已进行过研究，但未取得一致成功。然而，生长抑素类似物奥曲肽通过减缓胃排空、抑制胰岛素释放、减少肠肽分泌以及水和钠的肠道吸收、减缓单糖吸收、增加肠道转运时间并防止血流动力学变化来缓解倾倒症状。奥曲肽的短期疗效已在五项随机对照试验中得到证实。对少数患者的长期研究也取得了有前景的结果。
