Chang J H, Becker A, Ferguson A, Manfreda J, Simons E, Chan H, Noertjojo K, Chan-Yeung M
Department of Medicine, University of British Columbia.
Ann Allergy Asthma Immunol. 1996 Sep;77(3):187-90. doi: 10.1016/S1081-1206(10)63253-X.
Several acaricides have become available for reducing house dust mite allergen levels.
The purpose of this study was to assess whether the use of benzyl benzoate (Acarosan) provides additional benefit to the usual mite control measures including encasement of mattress and pillows with vinyl covers.
A randomized controlled trial was carried out in 26 homes (14 control versus 12 treatment) of asthmatic patients in two cities (Vancouver and Winnipeg). The control group had the usual house dust mite control measures including the use of vinyl covers for mattresses and pillows while the treatment group had application of benzyl benzoate to mattresses and carpets in the bedroom and the most commonly used room, in addition to the above control measures. Mite allergen levels were measured 3 months and immediately before, 1 week, and 1 and 3 months after the application of house dust mite control measures. Patients kept diary cards on asthma symptoms and peak expiratory flow rates morning and evening one month before and three months after the onset of mite allergen control measures.
A reduction of mite allergen level was found in mattress samples in both groups, statistically significant at all times in the treatment group and at one and three months in the control group. Mite allergen levels on floor carpets also showed progressive reduction in both groups, but were significantly different in the treatment group (compared with controls) at 1 week, and were lower compared with baseline in the treatment group up to 3 months. No significant changes in asthma symptoms, peak expiratory flow rates, spirometric measurements, or bronchial hyperresponsiveness were observed among treatment or control group subjects.
The addition of benzyl benzoate to conventional house dust mite control measures resulted in a significant reduction in floor carpet dust mite levels that persisted for 3 months. The results of this study should be confirmed in a larger and longer study.
已有多种杀螨剂可用于降低屋尘螨过敏原水平。
本研究旨在评估使用苯甲酸苄酯（Acarosan）是否能为包括用乙烯基床罩包裹床垫和枕头在内的常规螨虫控制措施带来额外益处。
在温哥华和温尼伯两个城市的26户哮喘患者家庭中进行了一项随机对照试验（14户为对照组，12户为治疗组）。对照组采取常规的屋尘螨控制措施，包括使用乙烯基床罩包裹床垫和枕头，而治疗组除上述控制措施外，还在卧室和最常用房间的床垫及地毯上涂抹苯甲酸苄酯。在采取屋尘螨控制措施前、措施实施后1周、1个月和3个月以及3个月时测量螨虫过敏原水平。患者在螨虫过敏原控制措施开始前1个月以及开始后3个月，每天早晚记录哮喘症状和呼气峰值流速的日记卡。
两组床垫样本中的螨虫过敏原水平均有所降低，治疗组在所有时间点均具有统计学意义，对照组在1个月和3个月时具有统计学意义。地板地毯上的螨虫过敏原水平在两组中也呈逐渐下降趋势，但治疗组在1周时与对照组相比有显著差异，且在3个月内治疗组与基线相比更低。治疗组或对照组受试者的哮喘症状、呼气峰值流速、肺功能测量或支气管高反应性均未观察到显著变化。
在传统的屋尘螨控制措施中添加苯甲酸苄酯可使地板地毯上的尘螨水平显著降低，并持续3个月。本研究结果应在规模更大、时间更长的研究中得到证实。
