van den Bemt Lisette, van Knapen Lieke, de Vries Marjolein P, Jansen Margreet, Cloosterman Sonja, van Schayck Constant P
Department of General Practice, Research Institute Caphri, Maastricht University, The Netherlands.
J Allergy Clin Immunol. 2004 Oct;114(4):858-62. doi: 10.1016/j.jaci.2004.05.069.
Exposure to allergens plays a role in the development of bronchial hyperresponsiveness and in the chronic inflammatory response seen in asthmatic patients. House dust mites (HDMs) are an important source of allergen. Reduction of these allergens might lead to better lung function and reduction of asthma symptoms.
The effect of HDM-impermeable covers on HDM allergen levels, peak flow values, and asthma symptoms were measured. Therefore a randomized clinical trial was carried out.
Fifty-two allergic asthmatic patients were randomly allocated to use the HDM-impermeable or placebo covers. During the study period, daily peak flow and asthma symptom scores were recorded. Dust samples were taken from the mattresses.
We observed a significant reduction in HDM allergen levels on the mattresses after encasing them with HDM-impermeable covers (reduction of 87% of Der p 1 in micrograms per gram of dust; P <.001). Baseline symptoms were so low that no improvement could be established. Morning peak expiratory flow is significantly higher in the intervention group compared with that seen in the placebo group during the study period (beta=20.2; P <.01).
HDM-impermeable covers significantly decreased the level of HDM allergens. Furthermore, morning peak flow was significantly increased during the intervention period. This study indicates that HDM allergen-avoidance measures might have beneficial effects on allergen reduction and asthma outcome.
接触过敏原在支气管高反应性的发展以及哮喘患者出现的慢性炎症反应中起作用。屋尘螨（HDM）是一种重要的过敏原来源。减少这些过敏原可能会使肺功能更好，并减轻哮喘症状。
测量HDM不可渗透床罩对HDM过敏原水平、峰值流速值和哮喘症状的影响。因此开展了一项随机临床试验。
52名过敏性哮喘患者被随机分配使用HDM不可渗透床罩或安慰剂床罩。在研究期间，记录每日峰值流速和哮喘症状评分。从床垫上采集灰尘样本。
我们观察到用HDM不可渗透床罩包裹床垫后，床垫上的HDM过敏原水平显著降低（每克灰尘中Der p 1减少87%；P<.001）。基线症状非常低，以至于无法确定有改善。在研究期间，干预组的早晨呼气峰值流速显著高于安慰剂组（β=20.2；P<.01）。
HDM不可渗透床罩显著降低了HDM过敏原水平。此外，在干预期早晨峰值流速显著增加。这项研究表明，避免HDM过敏原的措施可能对减少过敏原和哮喘病情转归有有益影响。
