Lama G, Amendola E, Aurino A M, Carbone M G, Valentino L, Iafusco F
Dipartimento di Pediatria II, Università degli Studi, Napoli.
Minerva Urol Nefrol. 1996 Jun;48(2):93-6.
The aim of the study has been to evaluate, retrospectively, if the association of urolithiasis different pathogenetic factors increases stone formation and recurrences. The study included 41 children, 20 males and 21 females, aged 3-15 years, divided into three groups: patients with hypercalciuric or normocalciuric urolithiasis and isolated hypercalciuria. In all of them renal function, blood and urinary pH, serum and urinary electrolytic levels, citraturia (dosed with anenzymatic quantitative method), oxalaturia (enzymatic colorimetric method), urinary glycosaminoglycans (dosed by means of cetylpyridinum chloride precipitation and quantitative analysis) have been considered. Statistical analysis was done using Student's "t"-test, with p < 0.05. In all children with hypercalciuric urolithiasis who during the follow-up presented a decreased citraturia, the number of recurrences increased and was above two. The children who during the follow-up remained hypercalciuric without urolithiasis, in spite of the high familiarity, presented an increased citraturia. In conclusion the association between hypercalciuria and low citraturia increases the risk of stone formation and recurrences in children with calcic urolithiasis.
本研究的目的是回顾性评估尿路结石不同致病因素的关联是否会增加结石形成和复发。该研究纳入了41名年龄在3至15岁之间的儿童，其中20名男性，21名女性，分为三组：高钙尿性或正常钙尿性尿路结石患者以及孤立性高钙尿症患者。对所有患者均考虑了肾功能、血液和尿液pH值、血清和尿液电解质水平、枸橼酸尿（采用酶定量法测定）、草酸尿（酶比色法）、尿糖胺聚糖（通过十六烷基吡啶氯化物沉淀和定量分析测定）。使用学生t检验进行统计分析，p < 0.05。在所有随访期间枸橼酸尿减少的高钙尿性尿路结石儿童中，复发次数增加且超过两次。尽管家族发病率高，但在随访期间仍为高钙尿症且无尿路结石的儿童，其枸橼酸尿增加。总之，高钙尿症与低枸橼酸尿之间的关联增加了儿童钙性尿路结石形成和复发的风险。
