Schwab G P, Wetscher G J, Vogl W, Redmond E
2nd Department of Surgery, University of Innsbruck, Austria.
Langenbecks Arch Chir. 1996;381(4):225-7. doi: 10.1007/BF00571690.
Cholestatic jaundice caused by imidazole derivates is a rare complication of antithyroid therapy. Only 20 such cases have been reported in the literature since the introduction of methimazole in 1949 and of carbimazole in 1953. We present a further case of methimazole-induced cholestatic liver injury, mimicking sclerosing cholangitis, where the etiology has been proven by a clear chronological relationship and the lack of other causative factors.
咪唑衍生物引起的胆汁淤积性黄疸是抗甲状腺治疗罕见的并发症。自1949年引入甲巯咪唑和1953年引入卡比马唑以来，文献中仅报道了20例此类病例。我们报告了另一例甲巯咪唑引起的胆汁淤积性肝损伤病例，其表现类似硬化性胆管炎，病因通过明确的时间关系及缺乏其他致病因素得以证实。
