George B, Kulkarni S K
Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India.
Methods Find Exp Clin Pharmacol. 1996 Jun;18(5):335-40.
Administration of subconvulsive dose of pilocarpine (30 mg/kg s.c.) to rats pretreated with lithium chloride (3 meq/kg i.p.) produced a state of status epilepticus in animals. The animals showed characteristic symptoms of generalized convulsions, wet dog shakes (WDS), forelimb clonus and falling back. The symptoms of status epilepticus (SE) developed within 26.8 +/- 3.6 min after administering pilocarpine and these symptoms continued uninterrupted. The phenomenon was totally reproducible, with a consistent latency of onset of seizures and a high mortality rate. The symptoms were blocked by atropine, scopolamine and the GABAergic agents GABA, sodium valproate, (+)-baclofen and clonazepam when given prior to pilocarpine, but not when administered 30 min after pilocarpine administration.
对预先腹腔注射氯化锂（3 毫当量/千克）的大鼠皮下注射亚惊厥剂量的毛果芸香碱（30 毫克/千克），会使动物出现癫痫持续状态。动物表现出全身惊厥、湿狗样抖动（WDS）、前肢阵挛和向后跌倒的特征性症状。癫痫持续状态（SE）的症状在注射毛果芸香碱后 26.8 +/- 3.6 分钟内出现，且这些症状持续不间断。该现象完全可重现，癫痫发作的潜伏期一致且死亡率高。在毛果芸香碱给药前给予阿托品、东莨菪碱和 GABA 能药物 GABA、丙戊酸钠、(+)-巴氯芬和氯硝西泮可阻断这些症状，但在毛果芸香碱给药 30 分钟后给药则无效。
