Lewitt M S, Scott F P, Clarke N M, Baxter R C
Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, Australia.
Prog Growth Factor Res. 1995;6(2-4):475-80. doi: 10.1016/0955-2235(95)00030-5.
The insulin-like growth factors (IGFs) and their binding properties (IGFBPs) are believed to play important roles in the growth and development of the human fetus. They have been implicated in the pathophysiology of pre-eclampsia. In this study we have characterized the developmental regulation, in normal and pre-eclamptic pregnancies, of IGFs and IGFBPs in maternal serum, neonatal serum and amniotic fluid. In neonatal cord serum IGFBP-1, -2 and -6 decreased with increasing gestational age. In contrast, the ternary complex and its components, IGF-I, IGFBP-3 and ALS increased with gestation. We show that while ALS is an important limiting factor for ternary complex formation in the fetal circulation, there is a fraction of IGFBP-3 which is unable to form this complex. IGFs and IGFBPs in the maternal and fetal circulation were similar in normal and pre-eclamptic pregnancies.
胰岛素样生长因子（IGFs）及其结合蛋白（IGFBPs）被认为在人类胎儿的生长发育中起重要作用。它们与先兆子痫的病理生理学有关。在本研究中，我们已对正常和先兆子痫妊娠中母体血清、新生儿血清和羊水中IGFs和IGFBPs的发育调节进行了表征。在新生儿脐带血清中，IGFBP - 1、- 2和- 6随胎龄增加而降低。相反，三元复合物及其成分IGF - I、IGFBP - 3和ALS随孕周增加而增加。我们表明，虽然ALS是胎儿循环中三元复合物形成的重要限制因素，但有一部分IGFBP - 3无法形成这种复合物。正常和先兆子痫妊娠中母体和胎儿循环中的IGFs和IGFBPs相似。
