Yoshikai M, Hamada M, Takarabe K, Okazaki Y, Ito T
Department of Cardiovascular Surgery, Koga Hospital, Kurume, Japan.
Artif Organs. 1996 Jun;20(6):704-6.
Centrifugal pumps have been used widely as the main pump in open heart surgery to reduce damage to blood elements and to reduce the activation of the coagulation system. The purpose of this study was the evaluation and comparison of the effects of two types of centrifugal pumps and of one type of roller pump on blood elements, the coagulation system, complements, and immunoglobulins. Two types of centrifugal pumps (Lifestream; St. Jude Medical, Chelmsford, Massachusetts; and BP-80: Medtronic, BioMedicus, Inc., Eden Prairie, Minnesota, U.S.A.) and one roller pump (Mera Co.) were used separately as the main pump for cardiopulmonary bypass (CPB) in 29 patients. Platelet counts, lactate dehydrogenase, antithrombin III, thrombin-antithrombin complex (TAT), complements (C3, C4, and CH50) and immunoglobulins G, A, and M values were measured before and after CPB and compared. Values, except those for TAT, showed no significant difference among the three groups. The TAT values increased less in each of the centrifugal pump groups than in the roller pump group. This finding suggests that thrombin synthesis might be suppressed by the use of a centrifugal pump.
离心泵已被广泛用作心脏直视手术中的主泵，以减少对血液成分的损伤并降低凝血系统的激活。本研究的目的是评估和比较两种类型的离心泵以及一种类型的滚压泵对血液成分、凝血系统、补体和免疫球蛋白的影响。两种类型的离心泵（Lifestream；美国马萨诸塞州切尔姆斯福德市圣犹达医疗公司；以及BP - 80：美国明尼苏达州伊甸草原市美敦力生物医学公司）和一种滚压泵（Mera Co.）分别作为29例患者体外循环（CPB）的主泵使用。在CPB前后测量血小板计数、乳酸脱氢酶、抗凝血酶III、凝血酶 - 抗凝血酶复合物（TAT）、补体（C3、C4和CH50）以及免疫球蛋白G、A和M的值并进行比较。除TAT值外，三组之间的值无显著差异。每个离心泵组的TAT值增加幅度均小于滚压泵组。这一发现表明使用离心泵可能会抑制凝血酶的合成。
