Düngemann H, von Mayenburg J, Rakoski J
Med Klin. 1977 Jun 17;72(24):1071-9.
90 patients with "hayfever" - that means pollenallergic diseases of the respiration tract and the eyes - were treated in spring 1974 and 1975 with a tyrosinabsorbed grass and rye depot extract with three injections before the pollen-season. Only 16 patients had an isolated grass-rye-pollen-allergy in skin test, all the other patients had additional extrinsic allergies. These results were proved by RAST. One third of the patients had bad side-effects (27 out of 90) during the treatment. 17 patients showed general reactions and ten patients very strong local reactions. We think that these side-effects were caused by contact with antigens (hairs of animals, foods, flowers of trees) during therapy and acute or chronic infections. The results of therapy were asked by a questionnaire one year after the series of injections, there were 37 improved, 32 unchanged and/or worsened in pollen-season after treatment. Nevertheless the results encouraged to continue this treatment with the grass-rye-pollen-extract. It could be used as an "initial treatment" in pollinosis patients with a wide spread allergy just before the beginning of the pollen-season. It is necessary to fullfill all procedures of precaution which are in use in hyposensitizationtherapy to prevent stronger side-effects.
1974年春季和1975年春季，对90例“花粉热”患者（即呼吸道和眼部的花粉过敏性疾病患者）使用酪氨酸吸附的禾本科和黑麦长效提取物进行治疗，在花粉季节前注射三次。皮肤试验中只有16例患者对禾本科和黑麦花粉有单一过敏，其他所有患者还存在其他外源性过敏。这些结果通过放射变应原吸附试验得到证实。三分之一的患者（90例中有27例）在治疗期间出现了严重的副作用。17例患者出现全身反应，10例患者出现非常强烈的局部反应。我们认为这些副作用是由治疗期间接触抗原（动物毛发、食物、树木花朵）以及急性或慢性感染引起的。在注射疗程结束一年后，通过问卷调查了解治疗效果，治疗后花粉季节中有37例病情改善，32例病情未改变和/或恶化。尽管如此，这些结果仍鼓励继续使用禾本科和黑麦花粉提取物进行治疗。它可在花粉季节开始前，作为广泛过敏的花粉症患者的“初始治疗”方法。必须遵循减敏疗法中使用的所有预防措施，以防止出现更严重的副作用。
