Lange K W, Paul G M, Naumann M, Gsell W
Department of Neuropsychology and Research Programme in Neuropsychology and Neurolinguistics, University of Freiburg, Federal Republic of Germany.
J Neural Transm Suppl. 1995;46:423-32.
A group of twelve patients with idiopathic Parkinson's disease was assessed both on and off L-Dopa medication on a range of tests of cognitive performance. Withdrawal of L-Dopa produced impairments in tests sensitive to frontal lobe dysfunction such as verbal fluency and the Tower of London task. Another test of frontal lobe function, the Wisconsin Card Sorting Test, was not affected in the absence of L-Dopa. Memory functions such as short-term span and verbal paired associate memory were not impaired by L-Dopa withdrawal. The results suggest that some of the cognitive impairments observed in Parkinson's disease, namely frontal lobe deficits, are related to a loss of central dopaminergic function.
一组12名特发性帕金森病患者在服用左旋多巴药物期间和停药后接受了一系列认知能力测试。停用左旋多巴会导致对额叶功能障碍敏感的测试出现损伤，如言语流畅性和伦敦塔任务。另一项额叶功能测试——威斯康星卡片分类测试，在停用左旋多巴时未受影响。记忆功能，如短期记忆广度和言语配对联想记忆，在停用左旋多巴后并未受损。结果表明，帕金森病中观察到的一些认知损伤，即额叶缺陷，与中枢多巴胺能功能丧失有关。
