Fritze J, Walden J
Department of Psychiatry, University of Frankfurt, Federal Republic of Germany.
J Neural Transm Suppl. 1995;46:439-53.
Calcium toxicity seems to be involved in ischemic brain lesions like in vascular dementia and possibly in primary degenerative dementia of Alzheimer's type. The calcium channel blocker nimodipine readily passes the blood-brain barrier and may thus serve as a pharmacologic probe to test the hypothesis of calcium toxicity. Although nimodipine proved to be superior to placebo in a considerable amount of studies in dementia the concept of calcium toxicity cannot be accepted as established. This is due to some methodological flaws in the clinical trials as well as the limited effect size. Moreover, bridging to other findings especially in Alzheimer-type dementia like amyloid deposition and the relationship to apolipoprotein-E isotypes is still far from complete.
钙毒性似乎与缺血性脑损伤有关，如血管性痴呆，也可能与阿尔茨海默病类型的原发性退行性痴呆有关。钙通道阻滞剂尼莫地平很容易通过血脑屏障，因此可以作为一种药理学探针来检验钙毒性假说。尽管在大量痴呆症研究中，尼莫地平被证明优于安慰剂，但钙毒性的概念尚未被确认为成立。这是由于临床试验中存在一些方法学缺陷以及效应量有限。此外，与其他发现的联系，尤其是在阿尔茨海默病型痴呆中的淀粉样蛋白沉积以及与载脂蛋白E异构体的关系，仍远未完善。
