[箭毒蛙毒素对有髓神经纤维膜中钠通道选择性的影响]
[Effect of batrachotoxin on the selectivity of sodium channels in the membrane of a myelinated nerve fiber].
作者信息
Revenko S V, Khodorov B I
出版信息
Neirofiziologiia. 1977;9(3):313-6.
PMID:882194
Abstract
Ionic currents under voltage clamp conditions were studied in the Ranvier node treated with batrachotoxin (5-10(-6)--10(-5) M). Ionic permeability ratios were measured from zero-current potential. The permeability sequence for modified (noninactivating) Na channels was: Tl greater than NH4 greater than Na approximately Li greater than K greater than guanidinum greater than Rb greater than Ca greater than Cs greater than methylamine. Deviation from the "independence relation" in modified channels for It1 was decreased.
摘要
在经蟾毒素（5×10⁻⁶ - 10⁻⁵M）处理的郎飞结中研究了电压钳制条件下的离子电流。从零电流电位测量离子渗透比。修饰（非失活）钠通道的渗透顺序为：铊＞铵＞钠≈锂＞钾＞胍＞铷＞钙＞铯＞甲胺。修饰通道中It1对“独立性关系”的偏离减小。
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[Effect of batrachotoxin on the selectivity of sodium channels in the membrane of a myelinated nerve fiber].[箭毒蛙毒素对有髓神经纤维膜中钠通道选择性的影响]
Neirofiziologiia. 1977;9(3):313-6.
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引用本文的文献
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Identification of new batrachotoxin-sensing residues in segment IIIS6 of the sodium channel.鉴定钠离子通道 IIIS6 片段中新型蛙毒素感应残基。
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