Chiba W, Sawai S, Yasuda Y, Wazawa H, Matsubara Y, Ikeda S
Respiratory Disease Center, Kyoto Katsura Hospital, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1995 Dec;33(12):1348-54.
The c-myc and p53 genes are thought to be an oncogene and a tumor suppressor gene, respectively. These genes' products are characteristic of malignant tumors. We quantitatively analyzed the c-myc and p53 products by flow cytometry in two cases of pulmonary sclerosing hemangioma. In case 1, 32.3% of the tumor cells were found to have the c-myc product, and 8.9% were found to have the p53 product. In case 2, 6.7% of the tumor cells were found to have the c-myc product and 15.5% were found to have the p53 product. The percentages in both cases were twice as high as those in a negative control lymphocytes stained with c-myc and p53 products. Therefore, these two cases showed positive expression of the c-myc and p53 products. In addition DNA from six other patients with sclerosing hemangioma was analyzed with paraffin-embedded sections. All six had DNA diploidy, with DNA indexes ranging from 0.91 to 1.03 and coefficients of variation ranging from 3.0 to 5.5. We suggest that pulmonary sclerosing hemangioma is a very weakly malignant tumor.
c-myc基因和p53基因分别被认为是一种癌基因和一种肿瘤抑制基因。这些基因的产物是恶性肿瘤的特征。我们通过流式细胞术对两例肺硬化性血管瘤中的c-myc和p53产物进行了定量分析。在病例1中，发现32.3%的肿瘤细胞有c-myc产物，8.9%有p53产物。在病例2中，发现6.7%的肿瘤细胞有c-myc产物，15.5%有p53产物。两例中的百分比均为用c-myc和p53产物染色的阴性对照淋巴细胞中百分比的两倍。因此，这两例显示c-myc和p53产物呈阳性表达。此外，用石蜡包埋切片对其他6例硬化性血管瘤患者的DNA进行了分析。所有6例均为DNA二倍体，DNA指数范围为0.91至1.03，变异系数范围为3.0至5.5。我们认为肺硬化性血管瘤是一种恶性程度很低的肿瘤。
