Mocsary Z, Bradberry C W
Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA.
Brain Res. 1996 Jan 15;706(2):194-8. doi: 10.1016/0006-8993(95)01200-1.
The purpose of this study was to examine the differential effects of intraperitoneal ethanol on the mesoaccumbens dopamine (DA) system in Fischer 344 and Lewis rat strains, utilizing microdialysis in awake animals. At the lowest dose tested (0.5 g/kg), there were no changes in extracellular DA in the nucleus accumbens in either strain. There was a differential response to the intermediate dose of 1 g/kg ethanol, with an 84% increase in extracellular DA in the Fischer, but no change in Lewis rats. The highest dose administered (2 g/kg) did not induce significant increases in DA in either strain. These data demonstrate that the mesoaccumbens DA systems of Fischer and Lewis rat strains differ in their susceptibility to activation by ethanol, and suggest that the higher alcohol preference of Lewis rats is not associated with an enhanced DAergic response to acute experimental administration of ethanol.
本研究的目的是利用清醒动物的微透析技术，检测腹腔注射乙醇对Fischer 344和Lewis大鼠品系中脑伏隔核多巴胺（DA）系统的不同影响。在测试的最低剂量（0.5 g/kg）下，两种品系大鼠伏隔核细胞外DA均无变化。对于1 g/kg乙醇的中间剂量，出现了不同的反应，Fischer大鼠细胞外DA增加了84%，而Lewis大鼠则无变化。给予的最高剂量（2 g/kg）在两种品系中均未引起DA的显著增加。这些数据表明，Fischer和Lewis大鼠品系的中脑伏隔核DA系统对乙醇激活的敏感性不同，并表明Lewis大鼠较高的酒精偏好与急性实验性给予乙醇时增强的多巴胺能反应无关。
