Allard P, Marcusson J O, Ross S B
Department of Psychiatry, University of Umeå, Sweden.
Brain Res. 1996 Jan 15;706(2):347-50. doi: 10.1016/0006-8993(95)01345-8.
The binding of [3H]WIN 35,428 was studied in post-mortem human brain, including extrastriatal regions. In the putamen, dopamine almost completely inhibited the [3H]WIN 35,428 binding. Paroxetine inhibited the binding with similar affinity as cocaine, in the range 200-300 nM. In the frontal cortex, [3H]WIN 35,428 labelled cocaine- and alaproclate sensitive binding sites, of which a major fraction was of protein nature. The elucidation of the cocaine sensitive sites in the frontal cortex should be the subject of further research.
在包括纹状体以外区域的人类尸检大脑中研究了[3H]WIN 35,428的结合情况。在壳核中，多巴胺几乎完全抑制了[3H]WIN 35,428的结合。帕罗西汀以与可卡因相似的亲和力抑制结合，浓度范围为200 - 300 nM。在额叶皮质中，[3H]WIN 35,428标记了对可卡因和阿普氯铵敏感的结合位点，其中大部分是蛋白质性质的。额叶皮质中可卡因敏感位点的阐明应是进一步研究的主题。
