Catafau A M, Parellada E, Lomeña F, Bernardo M, Pavía J, Ros D, Setoain J
Department of Nuclear Medicine, Faculty of Medicine, University of Barcelonia, Spain.
Nucl Med Commun. 1996 Jun;17(6):480-4. doi: 10.1097/00006231-199606000-00005.
To determine the sensitivity of 99TCm-hexamethylpropylene amine oxime (99TCm-HMPAO) and a single-head SPET (single photon emission tomography) system in the detection of perfusion changes in the visual cortex due to different visual conditions, six normal healthy volunteers were studied under conditions of visual deprivation (blindfolded), visual stimulation (stroboscopic light) and baseline (dim light and eyes open). Visual cortex/whole-brain activity ratios, and the percentage of activity change between the different visual conditions were calculated after three-dimensional realignment of the images. The activity in the visual cortex was higher during visual stimulation than during the visual deprivation (P = 0.002, 17.6 +/- 8.6% increase) and baseline conditions (P = 0.009, 8.8 +/- 5.6% increase). Furthermore, the activity in the visual cortex was lower during the visual deprivation than in the baseline condition (P = 0.001, 8.1 +/- 2.9% decrease). 99TCm-HMPAO SPET, even with a single-head system, is capable of detecting changes in rCBF in the striate cortex, not only between conditions of visual stimulation and deprivation, but also between these two conditions and the baseline state.
为了确定锝-99m六甲基丙烯胺肟（99TCm-HMPAO）和单探头单光子发射断层扫描（SPET）系统在检测不同视觉条件下视皮质灌注变化方面的敏感性，对6名正常健康志愿者在视觉剥夺（蒙眼）、视觉刺激（频闪灯）和基线（暗光且睁眼）条件下进行了研究。在对图像进行三维重新定位后，计算视皮质/全脑活动比率以及不同视觉条件之间的活动变化百分比。视皮质的活动在视觉刺激期间高于视觉剥夺期间（P = 0.002，增加17.6 +/- 8.6%）和基线条件下（P = 0.009，增加8.8 +/- 5.6%）。此外，视皮质的活动在视觉剥夺期间低于基线条件（P = 0.001，减少8.1 +/- 2.9%）。即使使用单探头系统，99TCm-HMPAO SPET也能够检测纹状皮质中局部脑血流的变化，不仅能检测视觉刺激和剥夺条件之间的变化，还能检测这两种条件与基线状态之间的变化。
