Shikare S V, Bashir K, Abraham P, Tilve G H
Department of Nuclear Medicine, Seth G.S. Medical College, Bombay, India.
Nucl Med Commun. 1996 Jun;17(6):520-2. doi: 10.1097/00006231-199606000-00011.
The hepatic perfusion index (HPI), the ratio of hepatic arterial to total liver blood flow, was determined by radionuclide angiography in 28 subjects with normal livers and 62 patients with portal hypertension of various aetiologies. The latter group comprised 50 patients with cirrhosis (14 Child class A, 20 Child class B, 16 Child class C) and 12 patients with non-cirrhotic portal hypertension (7 non-cirrhotic portal fibrosis, 5 extrahepatic portal venous obstruction). The mean (+/- S.D.) HPI was significantly higher among the patients with cirrhosis (Child class A, 53.9 +/- 18.1; Child class B, 65.6 +/- 29.4; Child class C, 78.6 +/- 33.5) and non-cirrhotic portal hypertension (54.9 +/- 17.7) compared with the subjects with normal livers (35.6 +/- 10.5). The patients with non-cirrhotic portal hypertension had a mean value similar to that of the cirrhotic patients in Child class A. A higher HPI was associated with worsening liver status. We conclude, therefore, that the HPI will be high in portal hypertension irrespective of aetiology and a rise in the HPI may indicate a deterioration in the condition of the liver.
通过放射性核素血管造影术测定了28例肝脏正常的受试者以及62例患有各种病因门静脉高压症患者的肝灌注指数（HPI），即肝动脉血流与肝脏总血流之比。后一组包括50例肝硬化患者（Child A级14例，Child B级20例，Child C级16例）和12例非肝硬化门静脉高压患者（7例非肝硬化门静脉纤维化，5例肝外门静脉阻塞）。与肝脏正常的受试者（35.6±10.5）相比，肝硬化患者（Child A级，53.9±18.1；Child B级，65.6±29.4；Child C级，78.6±33.5）和非肝硬化门静脉高压患者（54.9±17.7）的平均（±标准差）HPI显著更高。非肝硬化门静脉高压患者的平均值与Child A级肝硬化患者相似。较高的HPI与肝脏状况恶化相关。因此，我们得出结论，无论病因如何，门静脉高压时HPI都会升高，且HPI升高可能表明肝脏状况恶化。
