Kane J M
Department of Psychiatry, Hillside Hospital, Glen Oaks, NY 11004, USA.
J Clin Psychiatry. 1996;57 Suppl 9:35-40.
Despite the proven efficacy of antipsychotic medication in the treatment of schizophrenia, a substantial proportion of patients derive little if any benefit from traditional medications. Though alternative strategies (e.g., increasing dosage, switching antipsychotic, or adding adjunctive medication) are frequently employed, success rates are often disappointing. Clozapine has shown to be effective in some poor or partially responsive patients in three prospective, random assignment, double-blind trials. Risperidone has not yet been extensively studied in treatment-resistant patients, but may also be a useful alternative.
尽管抗精神病药物在治疗精神分裂症方面的疗效已得到证实，但相当一部分患者从传统药物中获益甚微或几乎没有获益。尽管经常采用替代策略（例如增加剂量、更换抗精神病药物或添加辅助药物），但成功率往往令人失望。在三项前瞻性、随机分组、双盲试验中，氯氮平已证明对一些疗效不佳或部分有反应的患者有效。利培酮尚未在难治性患者中进行广泛研究，但也可能是一种有用的替代药物。
