Meyer M, Uberbacher H J, Böhm E, Schöpe K B, Brett W, Forssmann W G
Niedersächsisches Institute for Peptide Research, Hanover, Germany.
Curr Opin Nephrol Hypertens. 1996 Jul;5(4):364-8. doi: 10.1097/00041552-199607000-00013.
Ularitide is a member of the natriuretic peptide family which is presumably synthesized in the kidney. In physiological experiments a correlation between Ularitide excretion and natriuresis has been found. Ularitide infusions and bolus injections in animals initiated profound diuresis and natriuresis as the most prominent effects. On the basis of findings in in-vitro and in-vivo experiments, Ularitide was used in clinical trials, and the results indicate that it could be a promising new drug to prevent and treat acute renal failure in patients after cardiac surgery and organ transplantation.
乌拉立肽是利钠肽家族的一员，可能在肾脏中合成。在生理学实验中，已发现乌拉立肽排泄与利钠作用之间存在相关性。在动物身上输注和推注乌拉立肽引发了显著的利尿和利钠作用，这是最突出的效应。基于体外和体内实验的结果，乌拉立肽被用于临床试验，结果表明它可能是预防和治疗心脏手术及器官移植后患者急性肾衰竭的一种有前景的新药。
