• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
The Saccharomyces cerevisiae MEC1 gene, which encodes a homolog of the human ATM gene product, is required for G1 arrest following radiation treatment.酿酒酵母的MEC1基因编码人类ATM基因产物的同源物，在辐射处理后G1期停滞中是必需的。
J Bacteriol. 1996 Oct;178(19):5841-3. doi: 10.1128/jb.178.19.5841-5843.1996.
2
The ATM homologue MEC1 is required for phosphorylation of replication protein A in yeast.酵母中复制蛋白A的磷酸化需要ATM同源物MEC1。
Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15075-80. doi: 10.1073/pnas.93.26.15075.
3
MEC1-dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks.MEC1 依赖的 Sir3 沉默蛋白从端粒到 DNA 双链断裂处的重新分布。
Cell. 1999 May 28;97(5):609-20. doi: 10.1016/s0092-8674(00)80772-2.
4
Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways.酵母细胞周期检查点途径中类ATM激酶MEC1和TEL1对RAD53的调控
Science. 1996 Jan 19;271(5247):357-60. doi: 10.1126/science.271.5247.357.
5
TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1.TEL1是人类共济失调毛细血管扩张症中发生突变的基因在酿酒酵母中的同源物，在功能上与酵母检查点基因MEC1相关。
Cell. 1995 Sep 8;82(5):831-40. doi: 10.1016/0092-8674(95)90480-8.
6
Characterization of mec1 kinase-deficient mutants and of new hypomorphic mec1 alleles impairing subsets of the DNA damage response pathway.mec1激酶缺陷型突变体以及损害DNA损伤反应途径亚群的新型mec1次等位基因的特征分析。
Mol Cell Biol. 2001 Jun;21(12):3913-25. doi: 10.1128/MCB.21.12.3913-3925.2001.
7
The budding yeast Rad9 checkpoint protein is subjected to Mec1/Tel1-dependent hyperphosphorylation and interacts with Rad53 after DNA damage.出芽酵母Rad9检查点蛋白会经历Mec1/Tel1依赖性的过度磷酸化，并在DNA损伤后与Rad53相互作用。
EMBO J. 1998 Oct 1;17(19):5679-88. doi: 10.1093/emboj/17.19.5679.
8
Cloning and characterization of RAD17, a gene controlling cell cycle responses to DNA damage in Saccharomyces cerevisiae.酿酒酵母中控制细胞周期对DNA损伤反应的基因RAD17的克隆与特性分析
Nucleic Acids Res. 1996 May 1;24(9):1669-75. doi: 10.1093/nar/24.9.1669.
9
RAD9 and RAD24 define two additive, interacting branches of the DNA damage checkpoint pathway in budding yeast normally required for Rad53 modification and activation.RAD9和RAD24定义了芽殖酵母中DNA损伤检查点途径的两个相加且相互作用的分支，这两个分支通常是Rad53修饰和激活所必需的。
EMBO J. 1998 May 1;17(9):2687-98. doi: 10.1093/emboj/17.9.2687.
10
Characterization of G1 checkpoint control in the yeast Saccharomyces cerevisiae following exposure to DNA-damaging agents.酿酒酵母暴露于DNA损伤剂后G1期检查点调控的特征分析
Genetics. 1994 Oct;138(2):271-81. doi: 10.1093/genetics/138.2.271.

引用本文的文献

1
The budding yeast protein Chl1p is required for delaying progression through G1/S phase after DNA damage.出芽酵母蛋白Chl1p是DNA损伤后延迟G1/S期进程所必需的。
Cell Div. 2021 Sep 8;16(1):4. doi: 10.1186/s13008-021-00072-x.
2
DNA resection proteins Sgs1 and Exo1 are required for G1 checkpoint activation in budding yeast.在芽殖酵母中，DNA 切除蛋白 Sgs1 和 Exo1 是 G1 检验点激活所必需的。
DNA Repair (Amst). 2013 Sep;12(9):751-60. doi: 10.1016/j.dnarep.2013.06.003. Epub 2013 Jul 6.
3
Implication of posttranslational histone modifications in nucleotide excision repair.翻译后修饰的组蛋白在核苷酸切除修复中的作用
Int J Mol Sci. 2012 Sep 28;13(10):12461-86. doi: 10.3390/ijms131012461.
4
Eukaryotic DNA damage checkpoint activation in response to double-strand breaks.真核生物 DNA 双链断裂损伤检验点的激活。
Cell Mol Life Sci. 2012 May;69(9):1447-73. doi: 10.1007/s00018-011-0875-3. Epub 2011 Nov 15.
5
Evidence that the histone methyltransferase Dot1 mediates global genomic repair by methylating histone H3 on lysine 79.证据表明，组蛋白甲基转移酶 Dot1 通过甲基化组蛋白 H3 赖氨酸 79 来介导全局基因组修复。
J Biol Chem. 2011 May 20;286(20):17530-5. doi: 10.1074/jbc.M111.241570. Epub 2011 Apr 1.
6
A role for checkpoint kinase-dependent Rad26 phosphorylation in transcription-coupled DNA repair in Saccharomyces cerevisiae.在酿酒酵母中，检查点激酶依赖性 Rad26 磷酸化在转录偶联的 DNA 修复中的作用。
Mol Cell Biol. 2010 Jan;30(2):436-46. doi: 10.1128/MCB.00822-09. Epub 2009 Nov 9.
7
Meiotic roles of Mec1, a budding yeast homolog of mammalian ATR/ATM.Mec1（哺乳动物ATR/ATM的芽殖酵母同源物）在减数分裂中的作用。
Chromosome Res. 2007;15(5):539-50. doi: 10.1007/s10577-007-1145-y.
8
Role of Dot1-dependent histone H3 methylation in G1 and S phase DNA damage checkpoint functions of Rad9.Dot1 依赖性组蛋白 H3 甲基化在 Rad9 的 G1 和 S 期 DNA 损伤检查点功能中的作用
Mol Cell Biol. 2005 Oct;25(19):8430-43. doi: 10.1128/MCB.25.19.8430-8443.2005.
9
Evidence of meiotic crossover control in Saccharomyces cerevisiae through Mec1-mediated phosphorylation of replication protein A.通过Mec1介导的复制蛋白A磷酸化在酿酒酵母中进行减数分裂交叉控制的证据。
Genetics. 2006 Jan;172(1):27-39. doi: 10.1534/genetics.105.047845. Epub 2005 Aug 22.
10
Germinating fission yeast spores delay in G1 in response to UV irradiation.发芽的裂殖酵母孢子在受到紫外线照射时会在G1期延迟。
BMC Cell Biol. 2004 Oct 21;5(1):40. doi: 10.1186/1471-2121-5-40.

本文引用的文献

1
The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species.ATM基因编码区的完整序列显示出与不同物种细胞周期调节因子的相似性。
Hum Mol Genet. 1995 Nov;4(11):2025-32. doi: 10.1093/hmg/4.11.2025.
2
Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways.酵母细胞周期检查点途径中类ATM激酶MEC1和TEL1对RAD53的调控
Science. 1996 Jan 19;271(5247):357-60. doi: 10.1126/science.271.5247.357.
3
Ataxia-telangiectasia and cellular responses to DNA damage.共济失调毛细血管扩张症与细胞对DNA损伤的反应。
Cancer Res. 1995 Dec 15;55(24):5991-6001.
4
Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene.野生型p53可介导mdm2基因内部启动子的序列特异性反式激活。
Oncogene. 1993 Dec;8(12):3411-6.
5
Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes?紫外线或电离辐射后转录活性p53的差异诱导：染色体不稳定综合征中的缺陷？
Cell. 1993 Nov 19;75(4):765-78. doi: 10.1016/0092-8674(93)90496-d.
6
p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest.辐射诱导人成纤维细胞G1期停滞过程中，p53依赖的细胞周期蛋白依赖性激酶活性抑制。
Cell. 1994 Mar 25;76(6):1013-23. doi: 10.1016/0092-8674(94)90379-4.
7
An essential gene, ESR1, is required for mitotic cell growth, DNA repair and meiotic recombination in Saccharomyces cerevisiae.在酿酒酵母中，一个必需基因ESR1对于有丝分裂细胞生长、DNA修复和减数分裂重组是必需的。
Nucleic Acids Res. 1994 Aug 11;22(15):3104-12. doi: 10.1093/nar/22.15.3104.
8
The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast.SAD1/RAD53蛋白激酶控制酵母中的多个检查点和DNA损伤诱导的转录。
Genes Dev. 1994 Oct 15;8(20):2401-15. doi: 10.1101/gad.8.20.2401.
9
Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair.芽殖酵母中的有丝分裂检查点基因以及有丝分裂对DNA复制和修复的依赖性。
Genes Dev. 1994 Mar 15;8(6):652-65. doi: 10.1101/gad.8.6.652.
10
The p53-dependent G1 cell cycle checkpoint pathway and ataxia-telangiectasia.p53 依赖的 G1 期细胞周期检查点通路与共济失调毛细血管扩张症。
Cancer Res. 1994 Oct 1;54(19):5054-8.

酿酒酵母的MEC1基因编码人类ATM基因产物的同源物，在辐射处理后G1期停滞中是必需的。

The Saccharomyces cerevisiae MEC1 gene, which encodes a homolog of the human ATM gene product, is required for G1 arrest following radiation treatment.

作者信息

Siede W, Allen J B, Elledge S J, Friedberg E C

机构信息

Division of Cancer Biology, Department of Radiation Oncology and Winship Cancer Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

出版信息

J Bacteriol. 1996 Oct;178(19):5841-3. doi: 10.1128/jb.178.19.5841-5843.1996.

DOI:10.1128/jb.178.19.5841-5843.1996
PMID:8824640
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC178434/
Abstract

The Saccharomyces cerevisiae gene MEC1 represents a structural homolog of the human gene ATM mutated in ataxia telangiectasia patients. Like human ataxia telangiectasia cell lines, mec1 mutants are defective in G2 and S-phase cell cycle checkpoints in response to radiation treatment. Here we show an additional defect in G1 arrest following treatment with UV light or gamma rays and map a defective arrest stage at or upstream of START in the yeast cell cycle.

摘要

酿酒酵母基因MEC1代表共济失调毛细血管扩张症患者中发生突变的人类基因ATM的结构同源物。与人类共济失调毛细血管扩张症细胞系一样，mec1突变体在接受放射治疗后，G2和S期细胞周期检查点存在缺陷。在此我们发现，经紫外线或γ射线处理后，mec1突变体在G1期停滞方面还存在缺陷，并将酵母细胞周期中存在缺陷的停滞阶段定位在START点或其上游。