未知交配阶段的连锁分析计分曲线。

Lod score curves for phase-unknown matings.

作者信息

Hulbert-Shearon T, Boehnke M, Lange K

机构信息

Department of Biostatistics, University of Michigan, Ann Arbor, USA.

出版信息

Hum Hered. 1996 Jan-Feb;46(1):55-7. doi: 10.1159/000154326.

DOI:10.1159/000154326

PMID:8825464

Abstract

For a phase-unknown nuclear family, we show that the likelihood and lod score are unimodal, and we describe conditions under which the maximum occurs at recombination fraction theta = 0, theta = 1/2, and 0 < theta < 1/2. These simply stated necessary and sufficient conditions seem to have escaped the notice of previous statistical geneticists.

摘要

对于一个相位未知的核心家庭，我们证明了似然值和对数优势分数是单峰的，并且我们描述了最大值出现在重组率θ = 0、θ = 1/2以及0 < θ < 1/2时的条件。这些表述简单的充分必要条件似乎被之前的统计遗传学家忽略了。