Crocq M A, Buguet A, Bisser S, Burgert E, Stanghellini A, Uyanik G, Dumas M, Macher J P, Mayerova A
Centre Hospitalier, FORENAP, Rouffach, France.
Hum Hered. 1996 Jan-Feb;46(1):58-60. doi: 10.1159/000154327.
An exonic BalI polymorphism and an intronic MspI polymorphism of the dopamine D3 gene were genotyped in 101 Caucasians from the Alsace and in 56 people from the Congo. This is the first study of the BalI polymorphism in sub-Saharan Africa and the first population study of the MspI site. BalI allele 1 was rare in the Congo (0.12) whereas it is the most frequent allele in all studies in Europe and Asia. MspI allele 1 was also significantly less frequent in the Congolese (0.24) than in Caucasians (0.52). D3 gene alleles show different frequencies in sub-Saharan Africa and may be useful for population studies.
对来自阿尔萨斯的101名高加索人和56名刚果人进行了多巴胺D3基因的外显子BalI多态性和内含子MspI多态性基因分型。这是撒哈拉以南非洲地区对BalI多态性的首次研究，也是对MspI位点的首次群体研究。BalI等位基因1在刚果人中很罕见（0.12），而在欧洲和亚洲的所有研究中它是最常见的等位基因。MspI等位基因1在刚果人中的频率（0.24）也显著低于高加索人（0.52）。D3基因等位基因在撒哈拉以南非洲地区表现出不同的频率，可能对群体研究有用。
