Strocchi P, Montanaro N, Dall'olio R
Pharmacol Biochem Behav. 1977 Apr;6(4):433-7. doi: 10.1016/0091-3057(77)90181-2.
The effect of a sublethal dose of alpha-amanitin given intraventricularly to rats on retention of passive and active avoidance conditioning has been studied, together with the effect on brain RNA and protein synthesis in vivo. The toxin brings about a significant impairment of retention of both passive and active conditioning in rats poisoned 6 hr or 24 before training. Brain RNA synthesis is decreased at 6 hr after poisoning, whilst protein synthesis decreases at a later stage (not before 12 hr after poisoning). Thus in rats poisoned with alpha-amanitin memory consolidation is impaired when RNA synthesis is decreased, and before protein synthesis is affected.
研究了向大鼠脑室内注射亚致死剂量的α-鹅膏蕈碱对被动和主动回避条件反射记忆保持的影响，以及对体内脑RNA和蛋白质合成的影响。在训练前6小时或24小时中毒的大鼠中，该毒素会导致被动和主动条件反射记忆保持显著受损。中毒后6小时脑RNA合成减少，而蛋白质合成在后期（中毒后12小时之前不会）减少。因此，在α-鹅膏蕈碱中毒的大鼠中，当RNA合成减少且在蛋白质合成受影响之前，记忆巩固就会受损。
