Kollöffel W J, Driessen F G, Goldhoorn P B
Department of Clinical Pharmacy, Twenteborg Hospital, Almelo, The Netherlands.
Pharm World Sci. 1996 Jun;18(3):105-8. doi: 10.1007/BF00417758.
An exploratory study in paediatric surgical patients was performed to describe the behaviour of a rectal solution of paracetamol at 20 mg/kg. Four of six patients were able to complete the study. Peak concentration (Cmax) and time to peak concentration (tmax) found in the children are comparable to adults studied earlier. After 1.6 hrs (tmax) a peak concentration of 11.7 mg/l (Cmax) was reached. The area under the curve (AUC t = 6) and the mean residence time (MRT) were respectively 48.3 mghr/l and 5.2 hrs. The solution appears promising for further study in daily clinical practise.
对儿科手术患者进行了一项探索性研究，以描述对乙酰氨基酚直肠溶液在20mg/kg剂量下的行为。六名患者中有四名能够完成研究。儿童中发现的峰值浓度（Cmax）和达到峰值浓度的时间（tmax）与早期研究的成年人相当。在1.6小时（tmax）后达到了11.7mg/l的峰值浓度（Cmax）。曲线下面积（AUC t = 6）和平均驻留时间（MRT）分别为48.3mghr/l和5.2小时。该溶液在日常临床实践中进行进一步研究似乎很有前景。
