Light J A, Gage F, Kowalski A E, Sasaki T M, Callender C O
Washington Hospital Center, Medlantic Research Institute/Howard University Hospital Organ Preservation Laboratory, Washington, D.C. 20010, USA.
Clin Transplant. 1996 Jun;10(3):233-6.
During a 1-yr period between September 1993 and September 1994, 74 patients received cadaveric kidney transplants at our institution. Thirty nine (39) kidneys were cold stored (CS), while 35 received pulsatile preservation (PP) on the Water's Mox system using U.W. Machine Preservation Solution. A perfusionist maintained pressure, flows, pH, and osmolality, within accepted ranges. Vasodilators (Regitine, Stelazine, Verapamil) were routinely added to the machine preservation solution. Most kidneys on PP were from marginal donors, or were imported and had associated long ice storage times. The CS kidneys, however, were from "ideal donors" where immediate function (IF) was expected. The kidneys were transplanted using a common protocol by a variety of surgeons. PP was associated with higher IF rates, shorter hospital stay and decreased overall costs. The function of those kidneys was also compared with the mate kidneys, obtained through a telephone survey of the various transplant centers throughout the country. PP was again associated with higher immediate function rates.
在1993年9月至1994年9月的1年期间，我们机构有74名患者接受了尸体肾移植。39个肾脏进行了冷保存（CS），而35个肾脏使用UW机器保存液在沃特斯莫克斯系统上进行了搏动性保存（PP）。一名灌注师将压力、流量、pH值和渗透压维持在可接受范围内。血管扩张剂（利其丁、氟奋乃静、维拉帕米）常规添加到机器保存液中。大多数接受PP的肾脏来自边缘供体，或者是进口的，并且有较长的冰储存时间。然而，CS组的肾脏来自预期有即时功能（IF）的“理想供体”。这些肾脏由不同的外科医生按照共同的方案进行移植。PP与更高的IF率、更短的住院时间和更低的总体成本相关。还通过对全国各移植中心的电话调查，将这些肾脏的功能与其配对肾脏进行了比较。PP再次与更高的即时功能率相关。
