Fábrega E, Casafont F, Merino J, de la Peña J, Crespo J, Amado J A, Pons-Romero F
Gastroenterology and Hepatology Unit, University Hospital Marques de Valdecilla, Faculty of Medicine, Santander, Spain.
Clin Transplant. 1996 Jun;10(3):261-5.
Recent data suggest that plasma P-selectin, an adhesion molecule, may be a clinically useful marker for thrombosis. Hepatic vessel thrombosis is one of the most serious complications following liver transplantation. To assess the contribution of the soluble P-selectin to this complication, we measured plasma P-selectin levels in 32 orthotopic liver transplantations, pre-, intra-, and post-operatively. We found that levels of circulating P-selectin were not different between cirrhotic patients and healthy subjects. Of the 32 patients, 8 had vascular complications. We found a significant increase in the plasma P-selectin concentration in the thrombotic group in early postoperative period compared with the non-thrombotic group (p < 0.002). It measurement may facilitate the diagnosis of thrombosis in the early postoperative period after liver transplantation, and therefore the management of these patients.
近期数据表明，血浆P-选择素（一种黏附分子）可能是一种对血栓形成具有临床实用价值的标志物。肝血管血栓形成是肝移植后最严重的并发症之一。为评估可溶性P-选择素对该并发症的影响，我们在32例原位肝移植患者术前、术中和术后测量了血浆P-选择素水平。我们发现肝硬化患者和健康受试者的循环P-选择素水平并无差异。32例患者中，8例出现血管并发症。我们发现，与非血栓形成组相比，血栓形成组术后早期血浆P-选择素浓度显著升高（p < 0.002）。该检测可能有助于肝移植术后早期血栓形成的诊断，从而有助于这些患者的治疗。
