Moran T H, Schwartz G J
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Crit Rev Neurobiol. 1994;9(1):1-28.
The peptide cholecystokinin (CCK) is widely distributed throughout the mammalian brain where it functions as a neurotransmitter and neuromodulator. CCK is colocalized with other neurotransmitters at a variety of brain sites. CCK receptor subtypes have been identified and their distributions mapped in the brain and the periphery. Exogenous CCK exerts a variety of effects depending on the site of administration, and many of these effects mimic actions of the endogenous peptide. Progress in understanding of the potential role of CCK in brain and behavior has focused on four main areas: CCK/dopamine interactions, CCK in anxiety and panic states, CCK in opioid nociception, and CCK in satiety. CCK's actions in modulating the activity of other neurotransmitters systems or in affecting behavior may serve as the bases for future therapeutic interventions.
缩胆囊素（CCK）肽广泛分布于整个哺乳动物脑内，在那里它作为一种神经递质和神经调质发挥作用。CCK与其他神经递质在脑内的多个部位共定位。CCK受体亚型已被鉴定出来，其分布也已在脑和外周绘制出来。外源性CCK根据给药部位会产生多种效应，其中许多效应模拟了内源性肽的作用。在理解CCK在脑和行为中的潜在作用方面的进展主要集中在四个主要领域：CCK/多巴胺相互作用、CCK在焦虑和惊恐状态中的作用、CCK在阿片类药物痛觉感受中的作用以及CCK在饱腹感中的作用。CCK在调节其他神经递质系统活性或影响行为方面的作用可能为未来的治疗干预提供基础。
