McMillian M K, Hong J S
Laboratory of Molecular and Integrative Neuroscience, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.
Crit Rev Neurobiol. 1994;9(1):91-103.
Cultured glial cells synthesize a number of neuropeptides, growth factors, cytokines, and other factors that are not detectable in resting glia in the adult brain but that appear in response to brain injury. Enkephalin-containing peptides are produced and released by cultured astrocytes and glioma cell lines, which have provided convenient model systems to study the regulation of the preproenkephalin gene. The purpose of this review is to examine data suggesting that reactive astrocytes produce enkephalin-containing peptides, the regulatory processes that may be involved, and possible functions of glia-derived peptides in reactive gliosis.
培养的神经胶质细胞能合成多种神经肽、生长因子、细胞因子以及其他一些在成年大脑静息神经胶质细胞中无法检测到，但在脑损伤时会出现的因子。含脑啡肽的肽由培养的星形胶质细胞和胶质瘤细胞系产生并释放，这些细胞系为研究前脑啡肽原基因的调控提供了便利的模型系统。本综述的目的是研究相关数据，这些数据表明反应性星形胶质细胞会产生含脑啡肽的肽、可能涉及的调控过程以及神经胶质细胞衍生肽在反应性胶质增生中的可能功能。
