Bosmann H B, Hales K H, Li X, Liu Z, Stocco D M, Hales D B
Department of Physiology and Biophysics, University of Illinois at Chicago, College of Medicine 60612-7342, USA.
Endocrinology. 1996 Oct;137(10):4522-5. doi: 10.1210/endo.137.10.8828518.
In an experimental endotoxemia model utilizing mice, serum testosterone was found to be decreased 90% two h post ip injection of 200 micrograms of lipopolysaccharide (LPS). This decrease was sustained for 9 days. The early depression of serum testosterone was shown to be associated with a decrease in Steroidogenic Acute Regulatory (StAR) protein levels while the prolonged decrease corresponded to decreased protein and transcript levels of steroidogenic enzymes in Leydig cells. This acute and prolonged depression of testosterone production could lead to impaired spermatogenesis, accessory duct failure, and contribute to decreased male fertility following acute inflammation.
在利用小鼠建立的实验性内毒素血症模型中，腹腔注射200微克脂多糖（LPS）两小时后，血清睾酮水平下降了90%。这种下降持续了9天。血清睾酮的早期降低与类固醇生成急性调节蛋白（StAR）水平的降低有关，而睾酮水平的持续降低则与睾丸间质细胞中类固醇生成酶的蛋白和转录水平降低相对应。睾酮生成的这种急性和持续性降低可能导致精子发生受损、附属性腺功能障碍，并导致急性炎症后男性生育能力下降。
