急性中毒时的脑铅和血铅

Brain and blood lead in acute intoxication.

作者信息

Savolainen H, Kilpiö J

出版信息

Scand J Work Environ Health. 1977 Jun;3(2):104-7. doi: 10.5271/sjweh.2788.

Abstract

Administering lead acetate in drinking water to adult male rats resulted in an elevated lead content in blood and brain during 11 subsequent days. The brain and blood lead contents were proportional to each other although the interdependency changed according to the cumulative dose and equilibration period. The present data indicate that the permeability of the blood-brain barrier towards inorganic lead may be dose-dependent and saturable with high doses of the metal.

摘要

给成年雄性大鼠饮用含醋酸铅的水，在随后的11天里，其血液和大脑中的铅含量升高。尽管相互依存关系会根据累积剂量和平衡期而变化，但大脑和血液中的铅含量是成比例的。目前的数据表明，血脑屏障对无机铅的通透性可能取决于剂量，并且在高剂量金属作用下会达到饱和。