O'Brien M J, Gibbons D
Department of Pathology, Boston University School of Medicine, Massachusetts, USA.
Surg Oncol Clin N Am. 1996 Jul;5(3):513-30.
In this article the epidemiologic, pathologic, molecular, and clinical evidence for the adenoma-carcinoma sequence is reviewed. The authors describe the morphologic evolution of the precursor adenomas, from the earliest discernible abnormality of the colon to adenomas with advanced pathologic features, the factors that determine the risk of progression of adenomas to adenocarcinoma, the molecular events that parallel or underlie the morphologic changes, the outcome of clinical interventions that have tested this hypothesis, and the time frame within which this progression is likely to occur.
本文回顾了腺瘤-癌序列的流行病学、病理学、分子学及临床证据。作者描述了前驱腺瘤的形态学演变，从结肠最早可辨别的异常到具有高级别病理特征的腺瘤，决定腺瘤进展为腺癌风险的因素，与形态学改变平行或作为其基础的分子事件，检验该假说的临床干预结果，以及这种进展可能发生的时间框架。
