• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

呼吸道合胞病毒所致疾病的免疫决定因素。

Immunological determinants of disease caused by respiratory syncytial virus.

作者信息

Graham B S

机构信息

Dept of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232-2605, USA.

出版信息

Trends Microbiol. 1996 Jul;4(7):290-3. doi: 10.1016/0966-842x(96)10032-9.

DOI:10.1016/0966-842x(96)10032-9
PMID:8829339
Abstract

Various disease syndromes caused by respiratory syncytial virus (RSV) may have a common mechanism of pathogenesis mediated by cytokines produced by type 2 T helper cells. The nature of the immune response to RSV is determined by the pattern of cytokines produced sequentially by many different cell types. Vaccination can influence the types of cytokine produced by selectively activating T cell subpopulations and inducing an immune response that clears the virus with minimal immunopathology.

摘要

呼吸道合胞病毒（RSV）引起的各种疾病综合征可能具有由2型辅助性T细胞产生的细胞因子介导的共同发病机制。对RSV的免疫反应性质由许多不同细胞类型依次产生的细胞因子模式决定。疫苗接种可通过选择性激活T细胞亚群并诱导以最小免疫病理学清除病毒的免疫反应来影响所产生的细胞因子类型。

相似文献

1
Immunological determinants of disease caused by respiratory syncytial virus.呼吸道合胞病毒所致疾病的免疫决定因素。
Trends Microbiol. 1996 Jul;4(7):290-3. doi: 10.1016/0966-842x(96)10032-9.
2
Cellular Immune Correlates Preventing Disease Against Respiratory Syncytial Virus by Vaccination with Virus-Like Nanoparticles Carrying Fusion Proteins.通过接种携带融合蛋白的病毒样纳米颗粒预防呼吸道合胞病毒疾病的细胞免疫关联
J Biomed Nanotechnol. 2017 Jan;13(1):84-98. doi: 10.1166/jbn.2017.2341.
3
Plasmid DNA encoding the respiratory syncytial virus G protein is a promising vaccine candidate.编码呼吸道合胞病毒G蛋白的质粒DNA是一种很有前景的候选疫苗。
Virology. 2000 Mar 30;269(1):54-65. doi: 10.1006/viro.2000.0186.
4
Virus-Like Particle Vaccine Containing the F Protein of Respiratory Syncytial Virus Confers Protection without Pulmonary Disease by Modulating Specific Subsets of Dendritic Cells and Effector T Cells.含有呼吸道合胞病毒F蛋白的病毒样颗粒疫苗通过调节树突状细胞和效应T细胞的特定亚群提供无肺部疾病的保护。
J Virol. 2015 Nov;89(22):11692-705. doi: 10.1128/JVI.02018-15. Epub 2015 Sep 9.
5
Cytokine pattern is solely influenced by priming vaccine but immunity and disease by both priming and boosting vaccines in mice challenged with respiratory syncytial virus.在用呼吸道合胞病毒攻击的小鼠中，细胞因子模式仅受启动疫苗的影响，但免疫和疾病受启动疫苗和加强疫苗两者的影响。
Virus Res. 2004 Jan;99(1):81-7. doi: 10.1016/j.virusres.2003.10.009.
6
Similar cytokine profiles in response to infection with respiratory syncytial virus type a and type B in the upper respiratory tract in infants.婴儿上呼吸道感染甲型和乙型呼吸道合胞病毒时相似的细胞因子谱。
Intervirology. 2008;51(2):112-5. doi: 10.1159/000134268. Epub 2008 May 21.
7
Both immunisation with a formalin-inactivated respiratory syncytial virus (RSV) vaccine and a mock antigen vaccine induce severe lung pathology and a Th2 cytokine profile in RSV-challenged mice.用福尔马林灭活的呼吸道合胞病毒（RSV）疫苗和模拟抗原疫苗进行免疫，均可在受RSV攻击的小鼠中诱发严重的肺部病理变化和Th2细胞因子谱。
Vaccine. 2000 Nov 22;19(7-8):982-91. doi: 10.1016/s0264-410x(00)00213-9.
8
Human respiratory syncytial virus: pathogenesis, immune responses, and current vaccine approaches.人类呼吸道合胞病毒：发病机制、免疫反应和当前疫苗方法。
Eur J Clin Microbiol Infect Dis. 2018 Oct;37(10):1817-1827. doi: 10.1007/s10096-018-3289-4. Epub 2018 Jun 6.
9
The role of IFN in respiratory syncytial virus pathogenesis.干扰素在呼吸道合胞病毒发病机制中的作用。
J Immunol. 2002 Mar 15;168(6):2944-52. doi: 10.4049/jimmunol.168.6.2944.
10
Alum Adjuvant Enhances Protection against Respiratory Syncytial Virus but Exacerbates Pulmonary Inflammation by Modulating Multiple Innate and Adaptive Immune Cells.明矾佐剂增强对呼吸道合胞病毒的保护作用，但通过调节多种固有免疫细胞和适应性免疫细胞加剧肺部炎症。
PLoS One. 2015 Oct 15;10(10):e0139916. doi: 10.1371/journal.pone.0139916. eCollection 2015.

引用本文的文献

1
Development of an intradermal DNA vaccine delivery strategy to achieve single-dose immunity against respiratory syncytial virus.开发一种皮内DNA疫苗递送策略以实现针对呼吸道合胞病毒的单剂量免疫。
Vaccine. 2017 May 15;35(21):2840-2847. doi: 10.1016/j.vaccine.2017.04.008. Epub 2017 Apr 14.
2
Circulating antibody-secreting cells during acute respiratory syncytial virus infection in adults.急性呼吸道合胞病毒感染期间成人循环抗体分泌细胞。
J Infect Dis. 2010 Dec 1;202(11):1659-66. doi: 10.1086/657158. Epub 2010 Oct 27.
3
Recent advancements for the evaluation of anti-viral activities of natural products.
天然产物抗病毒活性评估的最新进展。
N Biotechnol. 2009 Jun;25(5):347-68. doi: 10.1016/j.nbt.2009.03.007. Epub 2009 Apr 5.
4
Characterization of respiratory syncytial virus M- and M2-specific CD4 T cells in a murine model.小鼠模型中呼吸道合胞病毒M特异性和M2特异性CD4 T细胞的特征分析
J Virol. 2009 May;83(10):4934-41. doi: 10.1128/JVI.02140-08. Epub 2009 Mar 4.
5
Genetic association study for RSV bronchiolitis in infancy at the 5q31 cytokine cluster.5q31细胞因子簇处婴儿呼吸道合胞病毒细支气管炎的基因关联研究。
Thorax. 2009 Apr;64(4):345-52. doi: 10.1136/thx.2008.102111. Epub 2009 Jan 8.
6
Epidemiologic, experimental, and clinical links between respiratory syncytial virus infection and asthma.呼吸道合胞病毒感染与哮喘之间的流行病学、实验及临床联系。
Clin Microbiol Rev. 2008 Jul;21(3):495-504. doi: 10.1128/CMR.00054-07.
7
Treatment with anti-LFA-1 delays the CD8+ cytotoxic-T-lymphocyte response and viral clearance in mice with primary respiratory syncytial virus infection.用抗淋巴细胞功能相关抗原-1（anti-LFA-1）进行治疗会延迟原发性呼吸道合胞病毒感染小鼠中CD8 + 细胞毒性T淋巴细胞反应和病毒清除。
J Virol. 2004 Mar;78(6):3014-23. doi: 10.1128/jvi.78.6.3014-3023.2004.
8
Enhanced disease and pulmonary eosinophilia associated with formalin-inactivated respiratory syncytial virus vaccination are linked to G glycoprotein CX3C-CX3CR1 interaction and expression of substance P.与福尔马林灭活呼吸道合胞病毒疫苗接种相关的疾病加重和肺部嗜酸性粒细胞增多与G糖蛋白CX3C-CX3CR1相互作用及P物质的表达有关。
J Virol. 2003 Sep;77(18):9831-44. doi: 10.1128/jvi.77.18.9831-9844.2003.
9
Respiratory syncytial virus nucleoprotein-specific cytotoxic T-cell epitopes in a South African population of diverse HLA types are conserved in circulating field strains.在南非具有多种HLA类型的人群中，呼吸道合胞病毒核蛋白特异性细胞毒性T细胞表位在流行的野外毒株中是保守的。
J Virol. 2003 Jul;77(13):7319-29. doi: 10.1128/jvi.77.13.7319-7329.2003.
10
NK T cells contribute to expansion of CD8(+) T cells and amplification of antiviral immune responses to respiratory syncytial virus.自然杀伤T细胞有助于CD8(+) T细胞的扩增以及对呼吸道合胞病毒抗病毒免疫反应的增强。
J Virol. 2002 May;76(9):4294-303. doi: 10.1128/jvi.76.9.4294-4303.2002.