Tomasini C, Aloi F, Pippione M
Department of Dermatology, University of Turin, Italy.
Dermatology. 1996;192(2):160-3. doi: 10.1159/000246348.
We describe the histological and immunohistochemical findings of two cases of cellular neurothekeoma, a recently recognized benign neoplasm considered to be of neural origin. Morphologically they were characterized by a dermal proliferation of plexiform fascicles and small nests of pale eosinophilic, epithelioid or spindle-shaped cells which ramified in an ill-defined pattern between collagen bundles. Scant to moderate amounts of mucin were detected only in the plexiform lobules. Purely myxoid and cellular lobules concurred in these neoplasms. Immunohistochemically, both neoplasms exhibited focal immunoreactivity of the cells for factor XIIIa, providing further evidence for perineural differentiation. Problems of differential diagnosis with other plexiform neoplasms of uncertain origin are discussed.
我们描述了两例细胞性神经鞘瘤的组织学和免疫组化结果，这是一种最近才被认识的被认为起源于神经的良性肿瘤。形态学上，它们的特征是真皮内出现丛状束和小巢状淡嗜酸性、上皮样或梭形细胞增生，这些细胞在胶原束之间呈不明确的分支模式。仅在丛状小叶中检测到少量至中等量的黏蛋白。这些肿瘤中同时存在纯黏液样和细胞性小叶。免疫组化显示，这两种肿瘤的细胞均对因子ⅩⅢa呈局灶性免疫反应，为神经周分化提供了进一步证据。文中还讨论了与其他起源不明的丛状肿瘤的鉴别诊断问题。
