Hesse S, Jahnke M T, Luecke D, Mauritz K H
Department of Neurological Rehabilitation, Free University Berlin, Germany.
Neurosci Lett. 1995 Dec 1;201(1):37-40. doi: 10.1016/0304-3940(94)12124-9.
The study tested the spasmolytic effect of Botulinum toxin A in two groups of hemiparetic patients with lower limb spasticity: in the first group (n = 5) 2000 U Dysport were injected into the soleus, tibialis posterior and both heads of gastrocnemius muscles alone; the second (n = 5) received additional repetitive alternating electrical stimulation of M. tibialis anterior and plantar flexors for 30 min six times per day during the 3 days following the injection. Muscle tone, rated by the Ashworth spasticity score, and gait analysis including recording of vertical ground reaction forces, were assessed before and 4 weeks after injection. The combined treatment proved to be more effective with respect to the clinically assessed reduction of muscle tone, gait velocity, stride length, stance- and swing-symmetry (P < 0.05). The result is discussed with reference to animal experiments demonstrating enhanced toxin uptake and accelerated onset of its paralytic effect by electrical stimulation.
该研究在两组患有下肢痉挛的偏瘫患者中测试了A型肉毒杆菌毒素的解痉作用：第一组（n = 5）仅将2000 U的Dysport注射到比目鱼肌、胫后肌和腓肠肌的两个头中；第二组（n = 5）在注射后的3天内，每天6次接受胫前肌和跖屈肌的额外重复交替电刺激，持续30分钟。在注射前和注射后4周评估肌张力（通过Ashworth痉挛评分评定）以及步态分析，包括记录垂直地面反作用力。就临床评估的肌张力降低、步态速度、步幅长度、站立和摆动对称性而言，联合治疗被证明更有效（P < 0.05）。参考动物实验讨论了该结果，这些实验表明电刺激可增强毒素摄取并加速其麻痹作用的起效。
