Hargis A M, Thomassen R W, Phemister R D
Vet Pathol. 1977 May;14(3):218-28. doi: 10.1177/030098587701400304.
Chronic dermatosis developed in sparsely-haired, lightly pigmented, ventral body skin in 397 of 1 680 beagle dogs by the time the dogs were 5 1/2 years old. Twenty-six of 55 other beagles had developed by 12 years of age. Squamous cells carcinomas developed in the sites of dermatosis in eight of the 397 younger and five of the 26 older beagles. The lesions resembled solar keratosis (solar dermatosis, actinic dermatosis or senile keratosis) in man. They developed under circumstances suggesting that solar radiation is involved in the pathogenesis, as it is in man.
在1680只比格犬5岁半时，397只犬在毛发稀疏、色素较浅的腹部皮肤出现了慢性皮肤病。在另外55只比格犬中，有26只在12岁时出现了慢性皮肤病。在397只较年轻犬中，有8只在皮肤病部位发展为鳞状细胞癌；在26只较年长犬中，有5只出现了鳞状细胞癌。这些病变类似于人类的日光性角化病（日光性皮肤病、光化性皮肤病或老年角化病）。它们是在提示日光辐射参与发病机制的情况下发生的，就像在人类中一样。
