Chung J L, Kong M S, Lin S L, Lin T Y, Huang C S, Lou C C, Lin J N
Department of Paediatrics, Chang Gung Children's Hospital, Taoyuan, Taiwan, ROC.
Eur J Pediatr. 1996 Jul;155(7):529-31. doi: 10.1007/BF01957898.
The diagnostic value of serum C-reactive protein (CRP) levels in children with perforated appendicitis was prospectively studied in 78 consecutive patients with histologically confirmed appendicitis. The patients were divided into two groups: group A included 56 patients with perforated appendicitis and group B consisted of 22 patients with simple appendicitis. Serum CRP level and leucocyte count were assayed in all and abdominal ultrasonography was performed in 75. The mean age group A patient was significantly lower than that of group B patients (7.5 vs. 10.4 years, P < 0.001). Group A patients had a significantly higher mean serum CRP levels than group B patients (92 vs. 31 mg/l, P < 0.001), while the mean leucocyte count was comparable in the two groups. Of 75 examined patients, 73 (97%) had a pre-operative sonographic diagnosis of appendicitis.
Perforation is a common complication in children with appendicitis, especially in those of young age and with prolonged pain duration. Greatly increased serum CRP levels (> or = 50 mg/l) and abdominal ultrasonography are important diagnostic aids in such patients.
对78例经组织学确诊为阑尾炎的连续患儿，前瞻性研究血清C反应蛋白（CRP）水平对穿孔性阑尾炎患儿的诊断价值。将患者分为两组：A组包括56例穿孔性阑尾炎患者，B组由22例单纯性阑尾炎患者组成。对所有患者检测血清CRP水平和白细胞计数，75例患者进行腹部超声检查。A组患者的平均年龄显著低于B组患者（7.5岁对10.4岁，P<0.001）。A组患者的平均血清CRP水平显著高于B组患者（92mg/L对31mg/L，P<0.001），而两组的平均白细胞计数相当。在75例接受检查的患者中，73例（97%）术前超声诊断为阑尾炎。
穿孔是阑尾炎患儿的常见并发症，尤其是年龄小且疼痛持续时间长的患儿。血清CRP水平大幅升高（≥50mg/L）和腹部超声检查是此类患者重要的诊断辅助手段。
