Pankov A K, Chirvina E D, Tiutiunova A M
Vopr Onkol. 1977;23(4):21-4.
Under study was the excretion of 17-OCS and 17-KS in 2 male groups operated upon for lung cancer. The first group comprised 25 patients with the postoperative survival for less than a year. The second group-28 patients, whose survival was over 5 years postoperatively. In terms of 17-OCS excretion both groups were found to be identical: the level of 17OCS in them was normal. The excretion of 17-KS in patients of both groups proved to be considerably lower than normal values. However, in patients of the second group the level of 17-KS was higher, compared with the first group, mainly on account of androsterone. Thus, the balance of steroid hormones of glucocorticoid and androgenic series as well as the correlation between them may serve as a criterion of the prognosis for operated lung cancer patients.
对两组接受肺癌手术的男性患者的17-氧皮质类固醇(17-OCS)和17-酮类固醇(17-KS)排泄情况进行了研究。第一组包括25例术后存活期不到一年的患者。第二组有28例患者,其术后存活期超过5年。就17-OCS排泄而言,发现两组情况相同:他们体内的17-OCS水平正常。两组患者的17-KS排泄均明显低于正常值。然而,与第一组相比,第二组患者的17-KS水平较高,主要是由于雄酮。因此,糖皮质激素和雄激素系列类固醇激素的平衡及其之间的相关性可作为肺癌手术患者预后的一个标准。