Fukuda M, Hata A, Niwa S, Hiramatsu K, Honda H, Nakagome K, Iwanami A
Department of Neuropsychiatry, Faculty of Medicine, University of Tokyo, Japan.
Psychiatry Res. 1996 Jun 26;63(1):7-16. doi: 10.1016/0165-1781(96)02527-9.
The relationships between psychological stress responses and plasma levels of vanillylmandelic acid (VMA), 3-methoxy-4-hydroxyphenylglycol (MHPG), homovanillic acid (HVA), and 5-hydroxyindolacetic acid (5-HIAA) were investigated in normal volunteers. Two questionnaires were used to measure stress: the Psychological Stress Response Scale (PSRS) and the State-Trait Anxiety Inventory (STAI). Plasma levels of VMA--but not MHPG, HVA, and 5-HIAA--showed significant positive correlations with PSRS emotional and cognitive-behavioral stress and STAI state anxiety. Significant positive correlations were also found between plasma levels of VMA and MHPG and psychological stress responses measured repeatedly in a longitudinal study of an Olympic swimmer. Plasma VMA measurements, which reflect the level of activity of the peripheral sympathetic nervous system, may provide a useful biochemical index of psychological stress responses in normal subjects.
在正常志愿者中研究了心理应激反应与香草扁桃酸（VMA）、3-甲氧基-4-羟基苯乙二醇（MHPG）、高香草酸（HVA）和5-羟吲哚乙酸（5-HIAA）血浆水平之间的关系。使用两份问卷来测量应激：心理应激反应量表（PSRS）和状态-特质焦虑量表（STAI）。VMA的血浆水平——而非MHPG、HVA和5-HIAA——与PSRS情绪和认知行为应激以及STAI状态焦虑呈显著正相关。在一项对一名奥运游泳运动员的纵向研究中，多次测量的心理应激反应与VMA和MHPG的血浆水平之间也发现了显著正相关。反映外周交感神经系统活动水平的血浆VMA测量值，可能为正常受试者的心理应激反应提供一个有用的生化指标。
