Kaiser U, Auerbach B, Oldenburg M
Zentrum Innere Medizin, Abt.Hamatologie/Onkologie, Philipps-Universitat, Research Laboratories, Behringwerke AG, Marburg, Germany.
Leuk Lymphoma. 1996 Feb;20(5-6):389-95. doi: 10.3109/10428199609052420.
The Neural Cell Adhesion Molecule NCAM is a membrane glycoprotein and belongs to the immunoglobulin superfamily. It is expressed on neural cells as well as on various neuroendocrine tumors and can be detected in sera of patients with small cell lung cancer. Its role is attributed to tumor invasion and formation of metastases. Malignant plasma cells and a subset of plasma cells from patients with monoclonal gammopathy exhibit surface expression of NCAM whereas normal plasma cells do not express NCAM. Expression as measured by flow cytometry using anti-CD56 antibodies does not seem to correlate with clinical course, however leukemic myelomas and myeloma cell lines tend to loose NCAM surface expression. An isoform of NCAM which is rich in polysialic acids and characteristic for embryonal NCAM (eNCAM) has been shown to be elevated in sera of patients with multiple myeloma using a chemiluminescence immunoassay. Patients with progressive myeloma tend to have high serum NCAM levels above the normal range of 20 U/ml. Analysis of 125 myeloma patients suggest that serum NCAM is a valuable parameter for tumor progression rather than tumor mass. Increase in serum NCAM may be associated with loss of adhesive function.
神经细胞黏附分子NCAM是一种膜糖蛋白，属于免疫球蛋白超家族。它在神经细胞以及各种神经内分泌肿瘤上表达，并且在小细胞肺癌患者的血清中可以检测到。其作用归因于肿瘤侵袭和转移形成。恶性浆细胞以及来自单克隆丙种球蛋白病患者的一部分浆细胞表现出NCAM的表面表达，而正常浆细胞不表达NCAM。使用抗CD56抗体通过流式细胞术测量的表达似乎与临床病程无关，然而白血病性骨髓瘤和骨髓瘤细胞系倾向于失去NCAM表面表达。使用化学发光免疫测定法已显示，在多发性骨髓瘤患者的血清中，富含多唾液酸且具有胚胎NCAM（eNCAM）特征的NCAM同工型升高。进展性骨髓瘤患者的血清NCAM水平往往高于正常范围20 U/ml。对125例骨髓瘤患者的分析表明，血清NCAM是肿瘤进展而非肿瘤大小的一个有价值的参数。血清NCAM的增加可能与黏附功能丧失有关。
