Lindh U, Danersund A, Lindvall A
Division of Biomedical Radiation Sciences, Uppsala University, Sweden.
Cell Mol Biol (Noisy-le-grand). 1996 Feb;42(1):39-48.
Interaction between selenium and the heavy metals cadmium and mercury was studied in an experimental rat model (Sprague-Dawley). The rats were administered either one single trace element or combinations of selenium and cadmium as well as selenium and mercury. Salts of these trace elements were administered intraperitoneally daily during thirty days. Thereafter the animals were sacrificed and kidneys and livers excised rapidly. Thin sections were produced by a cryotome and subsequently freeze-dried. Nuclear microscopy of the sections showed that in the combination groups there was a co-localization of selenium and the heavy metals. None of the expected pathological signs of cadmium and mercury toxicity were observed. The conclusion was that selenium exerted a protective effect against the toxicity of cadmium and mercury through mechanisms still to be unveiled.
在一个实验大鼠模型（斯普拉格-道利大鼠）中研究了硒与重金属镉和汞之间的相互作用。给大鼠单独施用一种微量元素，或施用硒与镉以及硒与汞的组合。在三十天内每天经腹腔注射这些微量元素的盐。此后处死动物，并迅速切除肾脏和肝脏。用冷冻切片机制作薄片，随后进行冷冻干燥。对切片进行核显微镜检查表明，在组合组中硒与重金属存在共定位。未观察到镉和汞毒性的任何预期病理迹象。结论是，硒通过尚待揭示的机制对镉和汞的毒性发挥了保护作用。
